Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits
Other Title(s)
دراسة التأثير النسيجي و الجيني لعقار الترامادول على الأعضاء (الدماغ و الكبد و الكلية) في الأرانب البالغة
Author
Abd Allah, Buthaynah Abd al-Hamid
Source
The Iraqi Journal of Agricultural Science
Issue
Vol. 49, Issue 6 (31 Dec. 2018), pp.1083-1089, 7 p.
Publisher
University of Baghdad College of Agriculture
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
This study was to examine the histological changes in liver and kidney in tramadol -induced rabbits .
This study was conducted on 10 adult male rabbits.
Rabbits.
were divided evenly into two groups: control group, received 1 ml normal saline 0.9% Treated group received 0.3 ml of tramadol subcutaneously for 30 days.
Results: The histological analysis of the liver showed that the thickening wall with minimal fibrosis in the periportal area infiltration of inflammatory cells in necrotic change of the hepatocytes massive vacuolation of the hepatocyte, kupffer cell were present intensity in the sinusoid.
The histopathological examination of kidney revealed lymphocyte infiltration , congestion ,glomerulus and tubular damage.
The tubular was containing hypertrophied epithelial cell which block the lumen .Brain tissues in treated groups showed degeneration of pyramidal cells in the cortex , congestion of the blood vessels in the cortex and medulla.
The cortex certain pyramidal cell with slight enlarged.
The random amplified polymorphic DNA (RAPD) based on Polymerase Chain Reaction (PCR) with 5 primers were applied, used to estimate fingerprinting and Genetic Distance for 3organs .
the results showed clear difference in the number of packets as well as in the genetic dimension compared to the control group.
Conclusion: The histopathological and molecular alterations of liver, kidney and brain tissues threw lights on the possible risks of increased hepatic, renal and neurological damages evoked by repeated administration of tramadol for long periods.
American Psychological Association (APA)
Abd Allah, Buthaynah Abd al-Hamid. 2018. Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits. The Iraqi Journal of Agricultural Science،Vol. 49, no. 6, pp.1083-1089.
https://search.emarefa.net/detail/BIM-910847
Modern Language Association (MLA)
Abd Allah, Buthaynah Abd al-Hamid. Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits. The Iraqi Journal of Agricultural Science Vol. 49, no. 6 (2018), pp.1083-1089.
https://search.emarefa.net/detail/BIM-910847
American Medical Association (AMA)
Abd Allah, Buthaynah Abd al-Hamid. Histological and molecular studies of the effects of tramadol on brain, liver snd kidney of adult rabbits. The Iraqi Journal of Agricultural Science. 2018. Vol. 49, no. 6, pp.1083-1089.
https://search.emarefa.net/detail/BIM-910847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1089
Record ID
BIM-910847