A genetic polymorphism of interleukin 10 gene at position-1082 in Iraqis patients with type 1 diabetes of
المؤلفون المشاركون
Jasim, Azdihar Muhammad
Habib, Hanan Akram
Hassan, Ibtisam Badday
المصدر
Journal of al-Qadisiyah for Pure Science
العدد
المجلد 23، العدد 1 (31 مارس/آذار 2018)، ص ص. 17-23، 7ص.
الناشر
تاريخ النشر
2018-03-31
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the frequency of polymorphism of interleukin-10 Gene at position-1082 of the promoter region (IL-10-1082 SNP) in T1D and in healthy.
The subjects were determined in 39 Iraqi patients, (12 males & 27 females; 1 5.65 ± 1.79 years) and 21 controls (7 male and 14 female; 14.66 ± 3.43 years) by polymerase chain reaction-specific sequence primer (PCR-SSP) assay, followed by electrophoresis on agarose-gel.
The results revealed that comparing IL10 -1082 genotypes and alleles between T1D patients and controls it was observed that frequency of GA genotype was significantly higher (56.41vs.
42.85%; RR =23.7).
may be considered as a risk factor for T1D While A allele was not significantly in patients contrast to controls, (41.03vs.
40.48%; RR =0.9) and the associated EF values were 1.73and 1.02, respectively.
In contrast, GG genotype and G allele (30.76vs.
58.97%, P =0.579 respectively) frequencies were significantly decreased in patients, compared to controls (38.09vs.
59.52%; P =1.000), and the associated PF values were 0.72 and 0.98, respectively .
Similar observations were made in AA genotype.
These findings suggest that IL10-1082 polymorphism showed associations (positive and negative) with T1D in the samples of Iraqi patients .
Therefore, the functional role of such IL10-1082 might have been altered due to the deviations of some genotype and allele frequencies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassan, Ibtisam Badday& Jasim, Azdihar Muhammad& Habib, Hanan Akram. 2018. A genetic polymorphism of interleukin 10 gene at position-1082 in Iraqis patients with type 1 diabetes of. Journal of al-Qadisiyah for Pure Science،Vol. 23, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-913736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassan, Ibtisam Badday…[et al.]. A genetic polymorphism of interleukin 10 gene at position-1082 in Iraqis patients with type 1 diabetes of. Journal of al-Qadisiyah for Pure Science Vol. 23, no. 1 (2018), pp.17-23.
https://search.emarefa.net/detail/BIM-913736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassan, Ibtisam Badday& Jasim, Azdihar Muhammad& Habib, Hanan Akram. A genetic polymorphism of interleukin 10 gene at position-1082 in Iraqis patients with type 1 diabetes of. Journal of al-Qadisiyah for Pure Science. 2018. Vol. 23, no. 1, pp.17-23.
https://search.emarefa.net/detail/BIM-913736
نوع البيانات
مقالات
لغة النص
الإنجليزية
رقم السجل
BIM-913736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر