معالجة أورام الخلايا المنتشة الناكسة : دراسة مقارنة لطرائق العلاج المتبعة عالميا

الملخص EN

The principd of high-dose chemotherapy (HDCT) with autologous stem cell transplantation has been studied in both salvage and primary therapy setting in advanced and met.

germ cell tumor (GCT).

Previously the studies reported significant treatment-related mortality, introduction of peripheral blood stem cell transplantation, recombinant growth factors and better supportive care with G-CSF wich have decreased this toxicity and mortality.

High-dose chemotherapy (HDCT) is potentially curative in the second- and third-line therapy for patients with advanced germ cell tumor Two to three cycles of high-dose carboplatin and etoposide is the standard of HDCT, given with or without additional agents including ifosfamide, and paclitaxel.

Three large randomized Phase III trials have failed to show a benefit of HDCT over conventional-dose chemotherapy (CDCT) in the first-line treatment of patients with advanced GCT.

To date, the routine usage of HDCT has been reserved only for the salvage setting.

Patients with refractory or relapsed disease.

despite treatment under high-dose protocols, are generally considered to have incurable disease.

additional therapy is provided with palliative intent