The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata
المؤلفون المشاركون
al-Rabii, Sarah Isam
al-Fuḍayli, Zaynah Said
al-Tai, Abd al-Sami Hasan
المصدر
العدد
المجلد 16، العدد 4 (31 ديسمبر/كانون الأول 2019)، ص ص. 292-295، 4ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background: Alopecia areata (AA) is an autoimmune, dermatological, chronic, inflammatory disease that attacks hair follicles and causes hair loss.
Hair loss usually occurs on the scalp, but it can also affect the beard, eyebrows, and other areas of the body.
Interleukin‑2 (IL‑2) is a cytokine that contributes to the regulation of the immune system and is classified as a proinflammatory factor.
IL‑2 is an autocrine secretary element produced from activated T‑cells, exhibiting growth factor characteristics.
Objective: The objective of this study was to investigate the effect of the −330 IL‑2 gene polymorphism (rs2069762) on plasma IL‑2 levels in Iraqi patients with AA.
Materials and Methods: In this study, 100 patients with AA and 100 ethnicity‑, age‑, and sex‑matched healthy controls were selected.
Blood samples of all individuals were collected in EDTA tubes.
The restriction fragment length polymorphism–polymerase chain reaction method was applied to determine various alleles and genotypes in these individuals.
Plasma concentration of IL‑2 was measured in all the samples using human IL‑2 kit.
Results: The frequency of −330 G/T IL‑2 genotype was higher in patients with AA compared to normal individuals.
Accordingly, the plasma levels of IL‑2 were significantly higher (P < 0.0090) in patients when compared to the control group.
Conclusion: In case of patients with AA, the −330 G/T IL‑2 genotype is associated with higher plasma levels of IL‑2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Rabii, Sarah Isam& al-Tai, Abd al-Sami Hasan& al-Fuḍayli, Zaynah Said. 2019. The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata. Medical Journal of Babylon،Vol. 16, no. 4, pp.292-295.
https://search.emarefa.net/detail/BIM-935589
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rabii, Sarah Isam…[et al.]. The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata. Medical Journal of Babylon Vol. 16, no. 4 (Oct. / Dec. 2019), pp.292-295.
https://search.emarefa.net/detail/BIM-935589
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Rabii, Sarah Isam& al-Tai, Abd al-Sami Hasan& al-Fuḍayli, Zaynah Said. The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata. Medical Journal of Babylon. 2019. Vol. 16, no. 4, pp.292-295.
https://search.emarefa.net/detail/BIM-935589
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 295
رقم السجل
BIM-935589
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر