The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata
Joint Authors
al-Rabii, Sarah Isam
al-Fuḍayli, Zaynah Said
al-Tai, Abd al-Sami Hasan
Source
Issue
Vol. 16, Issue 4 (31 Dec. 2019), pp.292-295, 4 p.
Publisher
University of Babylon College of Medicine
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Abstract EN
Background: Alopecia areata (AA) is an autoimmune, dermatological, chronic, inflammatory disease that attacks hair follicles and causes hair loss.
Hair loss usually occurs on the scalp, but it can also affect the beard, eyebrows, and other areas of the body.
Interleukin‑2 (IL‑2) is a cytokine that contributes to the regulation of the immune system and is classified as a proinflammatory factor.
IL‑2 is an autocrine secretary element produced from activated T‑cells, exhibiting growth factor characteristics.
Objective: The objective of this study was to investigate the effect of the −330 IL‑2 gene polymorphism (rs2069762) on plasma IL‑2 levels in Iraqi patients with AA.
Materials and Methods: In this study, 100 patients with AA and 100 ethnicity‑, age‑, and sex‑matched healthy controls were selected.
Blood samples of all individuals were collected in EDTA tubes.
The restriction fragment length polymorphism–polymerase chain reaction method was applied to determine various alleles and genotypes in these individuals.
Plasma concentration of IL‑2 was measured in all the samples using human IL‑2 kit.
Results: The frequency of −330 G/T IL‑2 genotype was higher in patients with AA compared to normal individuals.
Accordingly, the plasma levels of IL‑2 were significantly higher (P < 0.0090) in patients when compared to the control group.
Conclusion: In case of patients with AA, the −330 G/T IL‑2 genotype is associated with higher plasma levels of IL‑2.
American Psychological Association (APA)
al-Rabii, Sarah Isam& al-Tai, Abd al-Sami Hasan& al-Fuḍayli, Zaynah Said. 2019. The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata. Medical Journal of Babylon،Vol. 16, no. 4, pp.292-295.
https://search.emarefa.net/detail/BIM-935589
Modern Language Association (MLA)
al-Rabii, Sarah Isam…[et al.]. The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata. Medical Journal of Babylon Vol. 16, no. 4 (Oct. / Dec. 2019), pp.292-295.
https://search.emarefa.net/detail/BIM-935589
American Medical Association (AMA)
al-Rabii, Sarah Isam& al-Tai, Abd al-Sami Hasan& al-Fuḍayli, Zaynah Said. The relationship between-330 Interleukin-2 gene polymorphism and its plasma levels in patients with alopecia areata. Medical Journal of Babylon. 2019. Vol. 16, no. 4, pp.292-295.
https://search.emarefa.net/detail/BIM-935589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 295
Record ID
BIM-935589