The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients
العناوين الأخرى
تأثير تراكم الحديد على وظائف بعض الغدد الصم عند مرضى فقر دم البحر الأبيض المتوسط نوع بيتا علاقة خاصة للهبسيدين
المؤلفون المشاركون
al-Khaqani, Manal Farhan Muhsin
al-Hakim, Husayn Kazim Abd al-Husayn
المصدر
al-Kufa University Journal for Biology
العدد
المجلد 5، العدد 2 (31 ديسمبر/كانون الأول 2013)22ص.
الناشر
جامعة الكوفة كلية العلوم قسم علوم الحياة
تاريخ النشر
2013-12-31
دولة النشر
العراق
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
Thalassemia is a term that refers to a group of genetic disorders characterized by a defect in the synthesis of hemoglobin.
It is sometimes called Mediterranean anemia.
Many biochemical changes in the blood accompany this disease.
In this research, some biochemical parameters were measured in thalassemic patients and compared with healthy control group.
These parameters include Serum iron, TIBC, were measured Spectrophotometrically.
Serum ferritin, Iisulin, GH, Testosterone, T3, T4, TSH, Cortisol, & Prolactine were measured by ELISA technique.
The results have revealed a moderate state of iron overload in the thalassemia patients.
Furthermore, there is a decrease in the level of serum cortisol, T4, prolactine and pancreatic beta cell function percentage (HOMA%B) in thalassemic while serum TSH level is higher in thalassemic patients in comparing with control group.
The changes in the hormone levels in addition to serum insulin, insulin/glucose ratio, and HOMA%B are correlated well with the degree of iron store in the body, concluded mainly from high ferritin level.Insulin resistance parameters showed a significant negative relation with Insulin sensitivity index.
There are significant increases in PCV, Hb, T3, and testosterone in male patients in comparing with female thalassemic patients.
From the results of the present study, it can be concluded that iron overload state affects some endocrine glands secretions and there is a difference in the effects between male and females in prepubertal thalassemic patients.
Therefore, it is important to estimate the endocrine function activity of thalassemia patients and treat the disorders if present as soon as possible.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hakim, Husayn Kazim Abd al-Husayn& al-Khaqani, Manal Farhan Muhsin. 2013. The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients. al-Kufa University Journal for Biology،Vol. 5, no. 2.
https://search.emarefa.net/detail/BIM-939720
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hakim, Husayn Kazim Abd al-Husayn& al-Khaqani, Manal Farhan Muhsin. The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients. al-Kufa University Journal for Biology Vol. 5, no. 2 (2013).
https://search.emarefa.net/detail/BIM-939720
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hakim, Husayn Kazim Abd al-Husayn& al-Khaqani, Manal Farhan Muhsin. The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients. al-Kufa University Journal for Biology. 2013. Vol. 5, no. 2.
https://search.emarefa.net/detail/BIM-939720
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-939720
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر