The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients
Other Title(s)
تأثير تراكم الحديد على وظائف بعض الغدد الصم عند مرضى فقر دم البحر الأبيض المتوسط نوع بيتا علاقة خاصة للهبسيدين
Joint Authors
al-Khaqani, Manal Farhan Muhsin
al-Hakim, Husayn Kazim Abd al-Husayn
Source
al-Kufa University Journal for Biology
Issue
Vol. 5, Issue 2 (31 Dec. 2013)22 p.
Publisher
University of Kufa Faculty of Science Department of live Sciences
Publication Date
2013-12-31
Country of Publication
Iraq
No. of Pages
22
Main Subjects
Abstract EN
Thalassemia is a term that refers to a group of genetic disorders characterized by a defect in the synthesis of hemoglobin.
It is sometimes called Mediterranean anemia.
Many biochemical changes in the blood accompany this disease.
In this research, some biochemical parameters were measured in thalassemic patients and compared with healthy control group.
These parameters include Serum iron, TIBC, were measured Spectrophotometrically.
Serum ferritin, Iisulin, GH, Testosterone, T3, T4, TSH, Cortisol, & Prolactine were measured by ELISA technique.
The results have revealed a moderate state of iron overload in the thalassemia patients.
Furthermore, there is a decrease in the level of serum cortisol, T4, prolactine and pancreatic beta cell function percentage (HOMA%B) in thalassemic while serum TSH level is higher in thalassemic patients in comparing with control group.
The changes in the hormone levels in addition to serum insulin, insulin/glucose ratio, and HOMA%B are correlated well with the degree of iron store in the body, concluded mainly from high ferritin level.Insulin resistance parameters showed a significant negative relation with Insulin sensitivity index.
There are significant increases in PCV, Hb, T3, and testosterone in male patients in comparing with female thalassemic patients.
From the results of the present study, it can be concluded that iron overload state affects some endocrine glands secretions and there is a difference in the effects between male and females in prepubertal thalassemic patients.
Therefore, it is important to estimate the endocrine function activity of thalassemia patients and treat the disorders if present as soon as possible.
American Psychological Association (APA)
al-Hakim, Husayn Kazim Abd al-Husayn& al-Khaqani, Manal Farhan Muhsin. 2013. The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients. al-Kufa University Journal for Biology،Vol. 5, no. 2.
https://search.emarefa.net/detail/BIM-939720
Modern Language Association (MLA)
al-Hakim, Husayn Kazim Abd al-Husayn& al-Khaqani, Manal Farhan Muhsin. The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients. al-Kufa University Journal for Biology Vol. 5, no. 2 (2013).
https://search.emarefa.net/detail/BIM-939720
American Medical Association (AMA)
al-Hakim, Husayn Kazim Abd al-Husayn& al-Khaqani, Manal Farhan Muhsin. The effect of iron overload on the function of some endocrine glands in β-thalassemia major patients. al-Kufa University Journal for Biology. 2013. Vol. 5, no. 2.
https://search.emarefa.net/detail/BIM-939720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-939720