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The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo
المؤلفون المشاركون
Yassa, Haidy A.
Mahran, Ayman Muhammad
Abd al-Azim, Najwa Isa
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 5، العدد 1 (31 مارس/آذار 2020)، ص ص. 41-45، 5ص.
الناشر
تاريخ النشر
2020-03-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background Topical immunoarm adulators have been successfully used as a monotherapy or in combination with other therapeutic modalities in vitiligo treatment.
Topical tacrolimus has been reported to promote melanoblast differentiation and groth.
Additionally, it promotes a favorable environement that enhances the proliferation of melanocytes/ melanoblasts through an interaction with keratinocytes, and thereby repopulating vitigiginous skin lesions.
Aim To detect the effect of tacrolimus ointements in treatment of nonsegmental vitiligo.
Method A total of 35 patients with vitiligo were enrolled in Tacrolimus this randomized placebo-controlled study.
Two vitiliginous patches were chosen in each patient.
The firstt lesion (A) was treated by tacrolimus 0.03% ointment, and the second lesion (B) was treated by panthenol cream as a placebo.
Treatment course was 3 months, and follow-up was done for three extra months.
Vitiliginous patches were assessed at baseline and monthly for 6 months.
Results Moderate to excellent response was observed in 25.7% of lesions A compared with 0% of lesions B (P = 0.002).
Disease duration has a negative effect on therapeutic response.
No adverse effects were noted to tacrolimus ointment except for mild erythema in 6% of the patients.
Coclusion Given its immunomodulatory properties and lack of cutaneous adverse effects, tacrolimus is a potential therapeutic alternative for vitiligo, with an improved benefit-risk ratio.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Azim, Najwa Isa& Yassa, Haidy A.& Mahran, Ayman Muhammad. 2020. The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo. Journal of Current Medical Research and Practice،Vol. 5, no. 1, pp.41-45.
https://search.emarefa.net/detail/BIM-956227
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Azim, Najwa Isa…[et al.]. The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo. Journal of Current Medical Research and Practice Vol. 5, no. 1 (Jan. / Mar. 2020), pp.41-45.
https://search.emarefa.net/detail/BIM-956227
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Azim, Najwa Isa& Yassa, Haidy A.& Mahran, Ayman Muhammad. The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo. Journal of Current Medical Research and Practice. 2020. Vol. 5, no. 1, pp.41-45.
https://search.emarefa.net/detail/BIM-956227
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 45
رقم السجل
BIM-956227
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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