The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo
Joint Authors
Yassa, Haidy A.
Mahran, Ayman Muhammad
Abd al-Azim, Najwa Isa
Source
Journal of Current Medical Research and Practice
Issue
Vol. 5, Issue 1 (31 Mar. 2020), pp.41-45, 5 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background Topical immunoarm adulators have been successfully used as a monotherapy or in combination with other therapeutic modalities in vitiligo treatment.
Topical tacrolimus has been reported to promote melanoblast differentiation and groth.
Additionally, it promotes a favorable environement that enhances the proliferation of melanocytes/ melanoblasts through an interaction with keratinocytes, and thereby repopulating vitigiginous skin lesions.
Aim To detect the effect of tacrolimus ointements in treatment of nonsegmental vitiligo.
Method A total of 35 patients with vitiligo were enrolled in Tacrolimus this randomized placebo-controlled study.
Two vitiliginous patches were chosen in each patient.
The firstt lesion (A) was treated by tacrolimus 0.03% ointment, and the second lesion (B) was treated by panthenol cream as a placebo.
Treatment course was 3 months, and follow-up was done for three extra months.
Vitiliginous patches were assessed at baseline and monthly for 6 months.
Results Moderate to excellent response was observed in 25.7% of lesions A compared with 0% of lesions B (P = 0.002).
Disease duration has a negative effect on therapeutic response.
No adverse effects were noted to tacrolimus ointment except for mild erythema in 6% of the patients.
Coclusion Given its immunomodulatory properties and lack of cutaneous adverse effects, tacrolimus is a potential therapeutic alternative for vitiligo, with an improved benefit-risk ratio.
American Psychological Association (APA)
Abd al-Azim, Najwa Isa& Yassa, Haidy A.& Mahran, Ayman Muhammad. 2020. The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo. Journal of Current Medical Research and Practice،Vol. 5, no. 1, pp.41-45.
https://search.emarefa.net/detail/BIM-956227
Modern Language Association (MLA)
Abd al-Azim, Najwa Isa…[et al.]. The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo. Journal of Current Medical Research and Practice Vol. 5, no. 1 (Jan. / Mar. 2020), pp.41-45.
https://search.emarefa.net/detail/BIM-956227
American Medical Association (AMA)
Abd al-Azim, Najwa Isa& Yassa, Haidy A.& Mahran, Ayman Muhammad. The efficacy, safety, and stability of tacrolimus 0.03% ointment in treatment of nonsegmental vitiligo. Journal of Current Medical Research and Practice. 2020. Vol. 5, no. 1, pp.41-45.
https://search.emarefa.net/detail/BIM-956227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 45
Record ID
BIM-956227