New mixed ligand cobalt (II III)‎ complexes based on the drug sodium valproate and bioactive nitrogen-donor ligands. synthesis, structure and biological properties

العناوين الأخرى

معقدات جديدة تشمل أيون الكوبالت (3+ 2+)‎ مع حمض الفالبرويت و القواعد النيتروجينية النشطة بيولوجيا التحضير، التركيب الهيكلي و الخصائص البيولوجية

مقدم أطروحة جامعية

Abu Shammah, Amani M.

مشرف أطروحة جامعية

Abu Ali, Hijazi

الجامعة

جامعة بيرزيت

الكلية

كلية العلوم

القسم الأكاديمي

دائرة الكيماء

دولة الجامعة

فلسطين (الضفة الغربية)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2016

الملخص الإنجليزي

New cobalt valproate complexes with different nitrogen based ligands were synthesized and characterized using various techniques such as IR, UV-Vis, single crystal X-ray diffraction as well as other physical properties.

The general formula of the prepared complexes is [Con(valp)m(L)z], (n = 1,2…; m = 1,2,…; Z = 1,2…).

The complexes [Co2(valp)4] (1), [Co(valp)2(2-ampy)2] (2), [Co2(valp)4(quin)2] (3), [Co(valp)2(2,9-dmp)] (4) and [Co(valp)2(H2O)(1,10-phen)] (5) showed different carboxylate coordination modes.

The crystal structure of the complexes 2, 3, 4 and 5 were solved by using single crystal X-ray diffraction.

In-vitro, anti-bacterial activities for the desired cobalt complexes were investigated against five gram-positive (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Enterococcus faecalis and Staphylococcus epidermidis) and four gram-negative bacteria (Escherichia coli, Klebsiella pneumonia, Proteus mirabilis and Pseudomonas aeruginosa) by using Agar diffusion method.

All cobalt valporate complexes didn’t show anti-bacterial activity against all gram-negative bacteria.

In addition, complex 3 didn’t exhibit any anti-bacterial activity against gram-positive bacteria.

Complex 2 only showed anti-bacterial activity against S.

aureus with IZD equal 17.5 mm.

Complex 4 showed good anti-bacterial activity against all gram-positive bacteria with IZD ranging between 15-28 mm.

Complex 5 showed low inhibition activity against all gram-positive bacteria except E.

faecalis with IZD ranging between 11.3-13.7 mm.

Also, the rate of BNPP hydrolysis was studied at different temperatures, pH and concentrations and found to be in the following order: 3 > 4 > 5 > 2.

التخصصات الرئيسية

الكيمياء

عدد الصفحات

114

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-957342