New mixed ligand cobalt (II III) complexes based on the drug sodium valproate and bioactive nitrogen-donor ligands. synthesis, structure and biological properties
Other Title(s)
معقدات جديدة تشمل أيون الكوبالت (3+ 2+) مع حمض الفالبرويت و القواعد النيتروجينية النشطة بيولوجيا التحضير، التركيب الهيكلي و الخصائص البيولوجية
Dissertant
Thesis advisor
University
Birzeit University
Faculty
Faculty of Science
Department
Department of Chemistry
University Country
Palestine (West Bank)
Degree
Master
Degree Date
2016
English Abstract
New cobalt valproate complexes with different nitrogen based ligands were synthesized and characterized using various techniques such as IR, UV-Vis, single crystal X-ray diffraction as well as other physical properties.
The general formula of the prepared complexes is [Con(valp)m(L)z], (n = 1,2…; m = 1,2,…; Z = 1,2…).
The complexes [Co2(valp)4] (1), [Co(valp)2(2-ampy)2] (2), [Co2(valp)4(quin)2] (3), [Co(valp)2(2,9-dmp)] (4) and [Co(valp)2(H2O)(1,10-phen)] (5) showed different carboxylate coordination modes.
The crystal structure of the complexes 2, 3, 4 and 5 were solved by using single crystal X-ray diffraction.
In-vitro, anti-bacterial activities for the desired cobalt complexes were investigated against five gram-positive (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Enterococcus faecalis and Staphylococcus epidermidis) and four gram-negative bacteria (Escherichia coli, Klebsiella pneumonia, Proteus mirabilis and Pseudomonas aeruginosa) by using Agar diffusion method.
All cobalt valporate complexes didn’t show anti-bacterial activity against all gram-negative bacteria.
In addition, complex 3 didn’t exhibit any anti-bacterial activity against gram-positive bacteria.
Complex 2 only showed anti-bacterial activity against S.
aureus with IZD equal 17.5 mm.
Complex 4 showed good anti-bacterial activity against all gram-positive bacteria with IZD ranging between 15-28 mm.
Complex 5 showed low inhibition activity against all gram-positive bacteria except E.
faecalis with IZD ranging between 11.3-13.7 mm.
Also, the rate of BNPP hydrolysis was studied at different temperatures, pH and concentrations and found to be in the following order: 3 > 4 > 5 > 2.
Main Subjects
No. of Pages
114
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Experimental.
Chapter Three : Results and discussion.
Chapter Four : Conclusion.
References.
American Psychological Association (APA)
Abu Shammah, Amani M.. (2016). New mixed ligand cobalt (II III) complexes based on the drug sodium valproate and bioactive nitrogen-donor ligands. synthesis, structure and biological properties. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-957342
Modern Language Association (MLA)
Abu Shammah, Amani M.. New mixed ligand cobalt (II III) complexes based on the drug sodium valproate and bioactive nitrogen-donor ligands. synthesis, structure and biological properties. (Master's theses Theses and Dissertations Master). Birzeit University. (2016).
https://search.emarefa.net/detail/BIM-957342
American Medical Association (AMA)
Abu Shammah, Amani M.. (2016). New mixed ligand cobalt (II III) complexes based on the drug sodium valproate and bioactive nitrogen-donor ligands. synthesis, structure and biological properties. (Master's theses Theses and Dissertations Master). Birzeit University, Palestine (West Bank)
https://search.emarefa.net/detail/BIM-957342
Language
English
Data Type
Arab Theses
Record ID
BIM-957342
