Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats
المؤلفون المشاركون
Ubayd, Halah Muhammad
Sulayman, Muhammad Talat A.
al-Tamai, Daliya A.
Juraysh, Sahar M.
Abd al-Raziq, Hibah Muhammad A.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 22، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 9-17، 9ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background: Bisphenol A (BPA) is a widely used and environmentally spread plasticizer.
BPA has various toxic effects, including immunological alterations.
Aim: Current work aimed to investigate the effect of BPA and protection with lycopene (LYC) on immunological parameters.
Material and Methods: Twenty-four male albino were divided into 4 equal groups.
Control group received corn oil, LYC group was given LYC 5 mg/kg,BPA group was given BPA at 5 mg/kg.
Last group was given combination of BPA and LYC the same previous doses.
Treatments were given daily via oral gavage for 4 weeks.
Weight gain, food conversion ratio (FCR), hematological parameters and lymphocytes proliferation assay were determined.
Serum total antioxidant capacity (TAC), malondialdehyde (MDA), interleukin-1β (IL-1β), Interleukin-12 (IL-12) and lymphocytes comet assay were evaluated.
Spleen and thymus histopathological assessment was done.
Results: BPA significantly (P<0.05) increased FCR while decreased lymphocytes proliferation than control group however, hematological parameters didn't alter.
Serum TAC was significantly (P<0.05) reduced in BPA group than control group while MDA, IL-1β and IL-12 were significantly (p<0.05) increased than control group.
Lymphocyte showed significant increase in comet tail and % of damage.
Thymus and spleen revealed mild lymphoid depletion.
Conclusion: BPA induced immunological perturbations that favors pro-inflammation and autoimmunity.
LYC administration ameliorated oxidative stress and lipid peroxidation induced immunological disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Raziq, Hibah Muhammad A.& al-Tamai, Daliya A.& Sulayman, Muhammad Talat A.& Juraysh, Sahar M.& Ubayd, Halah Muhammad. 2019. Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats. Suez Canal University Medical Journal،Vol. 22, no. 1, pp.9-17.
https://search.emarefa.net/detail/BIM-958768
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Raziq, Hibah Muhammad A.…[et al.]. Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats. Suez Canal University Medical Journal Vol. 22, no. 1 (2019), pp.9-17.
https://search.emarefa.net/detail/BIM-958768
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Raziq, Hibah Muhammad A.& al-Tamai, Daliya A.& Sulayman, Muhammad Talat A.& Juraysh, Sahar M.& Ubayd, Halah Muhammad. Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats. Suez Canal University Medical Journal. 2019. Vol. 22, no. 1, pp.9-17.
https://search.emarefa.net/detail/BIM-958768
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 15-17
رقم السجل
BIM-958768
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر