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Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats
Joint Authors
Ubayd, Halah Muhammad
Sulayman, Muhammad Talat A.
al-Tamai, Daliya A.
Juraysh, Sahar M.
Abd al-Raziq, Hibah Muhammad A.
Source
Suez Canal University Medical Journal
Issue
Vol. 22, Issue 1 (30 Jun. 2019), pp.9-17, 9 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2019-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background: Bisphenol A (BPA) is a widely used and environmentally spread plasticizer.
BPA has various toxic effects, including immunological alterations.
Aim: Current work aimed to investigate the effect of BPA and protection with lycopene (LYC) on immunological parameters.
Material and Methods: Twenty-four male albino were divided into 4 equal groups.
Control group received corn oil, LYC group was given LYC 5 mg/kg,BPA group was given BPA at 5 mg/kg.
Last group was given combination of BPA and LYC the same previous doses.
Treatments were given daily via oral gavage for 4 weeks.
Weight gain, food conversion ratio (FCR), hematological parameters and lymphocytes proliferation assay were determined.
Serum total antioxidant capacity (TAC), malondialdehyde (MDA), interleukin-1β (IL-1β), Interleukin-12 (IL-12) and lymphocytes comet assay were evaluated.
Spleen and thymus histopathological assessment was done.
Results: BPA significantly (P<0.05) increased FCR while decreased lymphocytes proliferation than control group however, hematological parameters didn't alter.
Serum TAC was significantly (P<0.05) reduced in BPA group than control group while MDA, IL-1β and IL-12 were significantly (p<0.05) increased than control group.
Lymphocyte showed significant increase in comet tail and % of damage.
Thymus and spleen revealed mild lymphoid depletion.
Conclusion: BPA induced immunological perturbations that favors pro-inflammation and autoimmunity.
LYC administration ameliorated oxidative stress and lipid peroxidation induced immunological disorders.
American Psychological Association (APA)
Abd al-Raziq, Hibah Muhammad A.& al-Tamai, Daliya A.& Sulayman, Muhammad Talat A.& Juraysh, Sahar M.& Ubayd, Halah Muhammad. 2019. Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats. Suez Canal University Medical Journal،Vol. 22, no. 1, pp.9-17.
https://search.emarefa.net/detail/BIM-958768
Modern Language Association (MLA)
Abd al-Raziq, Hibah Muhammad A.…[et al.]. Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats. Suez Canal University Medical Journal Vol. 22, no. 1 (2019), pp.9-17.
https://search.emarefa.net/detail/BIM-958768
American Medical Association (AMA)
Abd al-Raziq, Hibah Muhammad A.& al-Tamai, Daliya A.& Sulayman, Muhammad Talat A.& Juraysh, Sahar M.& Ubayd, Halah Muhammad. Effect of lycopene on bisphenol a-induced immunological disturbances in albino male rats. Suez Canal University Medical Journal. 2019. Vol. 22, no. 1, pp.9-17.
https://search.emarefa.net/detail/BIM-958768
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 15-17
Record ID
BIM-958768