Natural Killer T cells in Egyptian patients with HCV-associated Non-alcoholic fatty liver disease
المؤلفون المشاركون
Hasubah, Huwayda M.
Ali, Raghdah K.
Hasan, Adil A.
al-Saqqa, Amr A.
Imad, Rasha
Yunus, Suha Izz al-Din
Hasan, Amani M.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 22، العدد 1 (30 يونيو/حزيران 2019)، ص ص. 95-105، 11ص.
الناشر
تاريخ النشر
2019-06-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Background:Studies on Natural Killer T (NKT) cells in Non-alcoholic fatty liver disease (NAFLD) have shown contradictory results.
Moreover, the effect of HCV superinfection on NKT cells in NAFLD patients have not been previously studied.
Aim: to assess the effect of the concomitant HCV infection on the frequency of NKT cells and CD8+ T cells in a cohort of Egyptian patients with hepatic steatosis.
Subjects and Methods: Two-hundred subjects were divided into four equal groups, 1) concomitant hepatic steatosis/HCV, 2) HCV (without steatosis), 3) steatosis (without HCV), and 4) normal controls.
NKT and CD8+ T cells were identified by monoclonal antibodies surface staining for (CD3, CD56, CD161), and (CD3, CD8) respectively using flow cytometry.
Results: CD3+/CD56+/CD161+ NKT cells were significantly higher in patients with either steatosis (alone) or concomitant HCV/steatosis compared to control (p<0.0001 each), while comparable NKT frequency was found between HCV group and control (p=0.72).
A significant increase in CD3+/CD8+ T cells was noted in the three patients’ groups compared to control (p=0.0001, 0.002 and 0.001, respectively).
Interestingly, NKT cells were significantly higher in patients with steatosis/HCV compared to those with HCV alone (p<0.0001), while, they did not differ betweenconcomitant HCV/steatosis and steatosis (alone) group.
Higher frequencies of both NKT cells and CD8+ T cells were significantly associated with increased severity of steatosis.
In HCV group, NKT frequencies were unrelated to steatosis severity.
Conclusion: NKT cells are significantly elevated in patients with hepatic steatosis irrespective to the presence or absence of concomitant HCV infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Raghdah K.& Yunus, Suha Izz al-Din& Hasan, Adil A.& Hasan, Amani M.& al-Saqqa, Amr A.& Imad, Rasha…[et al.]. 2019. Natural Killer T cells in Egyptian patients with HCV-associated Non-alcoholic fatty liver disease. Suez Canal University Medical Journal،Vol. 22, no. 1, pp.95-105.
https://search.emarefa.net/detail/BIM-958786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Raghdah K.…[et al.]. Natural Killer T cells in Egyptian patients with HCV-associated Non-alcoholic fatty liver disease. Suez Canal University Medical Journal Vol. 22, no. 1 (2019), pp.95-105.
https://search.emarefa.net/detail/BIM-958786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Raghdah K.& Yunus, Suha Izz al-Din& Hasan, Adil A.& Hasan, Amani M.& al-Saqqa, Amr A.& Imad, Rasha…[et al.]. Natural Killer T cells in Egyptian patients with HCV-associated Non-alcoholic fatty liver disease. Suez Canal University Medical Journal. 2019. Vol. 22, no. 1, pp.95-105.
https://search.emarefa.net/detail/BIM-958786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 103-105
رقم السجل
BIM-958786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر