Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia
المؤلفون المشاركون
Abd al-Basit, Hisham A.
Abd al-Malak, Muhammad A. Y.
Mahran, Mahran M. H.
المصدر
Journal of Current Medical Research and Practice
العدد
المجلد 5، العدد 2 (30 يونيو/حزيران 2020)، ص ص. 152-157، 6ص.
الناشر
تاريخ النشر
2020-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction Hypersplenism is characterized by cytopenia, splenomegaly, and increased or normal bone marrow cellularity.
Platelet-associated immunoglobulin G (PAIgG) is a class of platelet autoantibodies bound to the surface glycoprotein of the platelet and is mainly produced by the spleen.
Significant higher PAIgG levels were found in patients with thrombocytopenic purpura and cirrhotic hypersplenism.
Aim The aim was to assess the antiplatelet immunoglobulin G antibodies level in patients with hypersplenism-associated thrombocytopenia before and after, first, medical treatment (growth factors and corticosteroids) and second, surgical treatment (splenectomy).
Patients and methods This study included 40 patients with hypersplenism and 10 age-matched and sex-matched healthy controls.
Serum antiplatelet IgG was measured by ELISA technique using Human antiplatelet IgG (anti-PA IgG) ELISA Kit.
Results In both the splenectomized and the medical groups, PAIgG had insignificant decrease during follow-up in comparison with baseline level (in case of the splenectomized group, 224.50 [+ or -] 51.32 vs 206.30 [+ or -] 69.82 µg/ml, P = 0.33, and in case of the medical group, 200.81 [+ or -] 55.41 vs 186.60 [+ or -] 72.29 µg/ml, P = 0.07).
Conclusion An immune process may be mediated by PAIgG, and secondary hypersplenism due to portal hypertension is associated with thrombocytopenia in patients with liver cirrhosis.
The authors also found that patients with splenomegaly subjected to splenectomy had a significant elevation of platelet counts and insignificant reduction in PAIgG levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Basit, Hisham A.& Abd al-Malak, Muhammad A. Y.& Mahran, Mahran M. H.. 2020. Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia. Journal of Current Medical Research and Practice،Vol. 5, no. 2, pp.152-157.
https://search.emarefa.net/detail/BIM-975089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Basit, Hisham A.…[et al.]. Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia. Journal of Current Medical Research and Practice Vol. 5, no. 2 (Apr. / Jun. 2020), pp.152-157.
https://search.emarefa.net/detail/BIM-975089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Basit, Hisham A.& Abd al-Malak, Muhammad A. Y.& Mahran, Mahran M. H.. Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia. Journal of Current Medical Research and Practice. 2020. Vol. 5, no. 2, pp.152-157.
https://search.emarefa.net/detail/BIM-975089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 156-157
رقم السجل
BIM-975089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر