Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia
Joint Authors
Abd al-Basit, Hisham A.
Abd al-Malak, Muhammad A. Y.
Mahran, Mahran M. H.
Source
Journal of Current Medical Research and Practice
Issue
Vol. 5, Issue 2 (30 Jun. 2020), pp.152-157, 6 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2020-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction Hypersplenism is characterized by cytopenia, splenomegaly, and increased or normal bone marrow cellularity.
Platelet-associated immunoglobulin G (PAIgG) is a class of platelet autoantibodies bound to the surface glycoprotein of the platelet and is mainly produced by the spleen.
Significant higher PAIgG levels were found in patients with thrombocytopenic purpura and cirrhotic hypersplenism.
Aim The aim was to assess the antiplatelet immunoglobulin G antibodies level in patients with hypersplenism-associated thrombocytopenia before and after, first, medical treatment (growth factors and corticosteroids) and second, surgical treatment (splenectomy).
Patients and methods This study included 40 patients with hypersplenism and 10 age-matched and sex-matched healthy controls.
Serum antiplatelet IgG was measured by ELISA technique using Human antiplatelet IgG (anti-PA IgG) ELISA Kit.
Results In both the splenectomized and the medical groups, PAIgG had insignificant decrease during follow-up in comparison with baseline level (in case of the splenectomized group, 224.50 [+ or -] 51.32 vs 206.30 [+ or -] 69.82 µg/ml, P = 0.33, and in case of the medical group, 200.81 [+ or -] 55.41 vs 186.60 [+ or -] 72.29 µg/ml, P = 0.07).
Conclusion An immune process may be mediated by PAIgG, and secondary hypersplenism due to portal hypertension is associated with thrombocytopenia in patients with liver cirrhosis.
The authors also found that patients with splenomegaly subjected to splenectomy had a significant elevation of platelet counts and insignificant reduction in PAIgG levels.
American Psychological Association (APA)
Abd al-Basit, Hisham A.& Abd al-Malak, Muhammad A. Y.& Mahran, Mahran M. H.. 2020. Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia. Journal of Current Medical Research and Practice،Vol. 5, no. 2, pp.152-157.
https://search.emarefa.net/detail/BIM-975089
Modern Language Association (MLA)
Abd al-Basit, Hisham A.…[et al.]. Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia. Journal of Current Medical Research and Practice Vol. 5, no. 2 (Apr. / Jun. 2020), pp.152-157.
https://search.emarefa.net/detail/BIM-975089
American Medical Association (AMA)
Abd al-Basit, Hisham A.& Abd al-Malak, Muhammad A. Y.& Mahran, Mahran M. H.. Role of platelet-associated immunoglobulin G in hypersplenism-associated thrombocytopenia. Journal of Current Medical Research and Practice. 2020. Vol. 5, no. 2, pp.152-157.
https://search.emarefa.net/detail/BIM-975089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 156-157
Record ID
BIM-975089