Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design

مقدم أطروحة جامعية

Aziz, Nur Firas

مشرف أطروحة جامعية

al-Ali, Samir Hasan Husayn
Gharib, Muwaffaq Muhammad

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2020

الملخص الإنجليزي

The aim of this study is to employ nanoparticles as drug carriers.

The study involved the preparation of theophylline chitosan nanoparticles (THP-CSNPs) to overcome problem of theophylline frequent dose and improve properties.

The THP-CSNPs samples were prepared using several amounts of CS (50, 75, 100 and 150 mg) and tripolyphosphate (TPP) at different amounts (25, 50, 75, 100, and 200 mg) and pH (4, 5, 6 and 6.5) with constant mass of THP at 100 mg.

The produced nanocomposites were characterized by Fourier Transform Infrared (FTIR) and in vitro release.

FTIR assessments were performed to estimate the functional group of THP loaded CS nanocomposites with any possible interaction.

Full factorial design (Minitab 18) for the purpose of analyzing the results by using graphical analysis such as surface and contour plots, Pareto chart, main effect plots, normal probability plot of the residuals and residuals versus corresponding predicted values plots and interaction plots.

The independent variable was (CS, TPP and pH) while loading efficiency, zeta potential and particle size are the dependent variables.

Through experiments, we were able to obtain theophylline-chitosan nanocomposites of an acceptable size range and high specefication, which succeeded to carry and preserve the drug and provide prolonged release of THP from the nanocomposites

التخصصات الرئيسية

علم الصيدلة

الموضوعات

عدد الصفحات

73

قائمة المحتويات

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Literature review.

Chapter Three : Methodology.

Chapter Four : Results and discussion.

Chapter Five : Conclusion.

References.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Aziz, Nur Firas. (2020). Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-985110

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Aziz, Nur Firas. Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design. (Master's theses Theses and Dissertations Master). Isra University. (2020).
https://search.emarefa.net/detail/BIM-985110

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Aziz, Nur Firas. (2020). Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-985110

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-985110