
Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design
Dissertant
Thesis advisor
al-Ali, Samir Hasan Husayn
Gharib, Muwaffaq Muhammad
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2020
English Abstract
The aim of this study is to employ nanoparticles as drug carriers.
The study involved the preparation of theophylline chitosan nanoparticles (THP-CSNPs) to overcome problem of theophylline frequent dose and improve properties.
The THP-CSNPs samples were prepared using several amounts of CS (50, 75, 100 and 150 mg) and tripolyphosphate (TPP) at different amounts (25, 50, 75, 100, and 200 mg) and pH (4, 5, 6 and 6.5) with constant mass of THP at 100 mg.
The produced nanocomposites were characterized by Fourier Transform Infrared (FTIR) and in vitro release.
FTIR assessments were performed to estimate the functional group of THP loaded CS nanocomposites with any possible interaction.
Full factorial design (Minitab 18) for the purpose of analyzing the results by using graphical analysis such as surface and contour plots, Pareto chart, main effect plots, normal probability plot of the residuals and residuals versus corresponding predicted values plots and interaction plots.
The independent variable was (CS, TPP and pH) while loading efficiency, zeta potential and particle size are the dependent variables.
Through experiments, we were able to obtain theophylline-chitosan nanocomposites of an acceptable size range and high specefication, which succeeded to carry and preserve the drug and provide prolonged release of THP from the nanocomposites
Main Subjects
Topics
No. of Pages
73
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Methodology.
Chapter Four : Results and discussion.
Chapter Five : Conclusion.
References.
American Psychological Association (APA)
Aziz, Nur Firas. (2020). Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-985110
Modern Language Association (MLA)
Aziz, Nur Firas. Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design. (Master's theses Theses and Dissertations Master). Isra University. (2020).
https://search.emarefa.net/detail/BIM-985110
American Medical Association (AMA)
Aziz, Nur Firas. (2020). Invistigating the effect of formulation variables on the preparation of chitosan-theophylline nanocomposite using quality by design. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-985110
Language
English
Data Type
Arab Theses
Record ID
BIM-985110