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Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria
المؤلفون المشاركون
Patel, Pooja
Joshi, Chinmayi
Kothari, Vijay
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-27
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
This study investigated antipathogenic efficacy of a polyherbal wound-healing formulation Herboheal against three multidrug-resistant strains of gram-negative bacterial pathogens associated with wound infections.
Herboheal was evaluated for its quorum-modulatory potential against three different human-pathogenic bacteria, first in vitro through the broth dilution assay and then in vivo in the model host Caenorhabditis elegans.
Herboheal at ≥0.1% v/v was able to inhibit (19–55%) in vitro production of quorum sensing-regulated pigments in all these bacteria and seemed to interfere with bacterial quorum sensing by acting as a signal-response inhibitor.
This formulation could compromise haemolytic activity of all three bacteria by ∼18–69% and induced their catalase activity by ∼8–21%.
Herboheal inhibited P.
aeruginosa biofilm formation up to 40%, reduced surface hydrophobicity of P.
aeruginosa cells by ∼9%, and also made them (25%) more susceptible to lysis by human serum.
Antibiotic susceptibility of all three bacteria was modulated owing to pretreatment with Herboheal.
Exposure of these test pathogens to Herboheal (≥0.025% v/v) effectively reduced their virulence towards the nematode Caenorhabditis elegans.
Repeated subculturing of P.
aeruginosa on the Herboheal-supplemented growth medium did not induce resistance to Herboheal in this mischievous pathogen, and this polyherbal extract was also found to exert a post-extract effect on P.
aeruginosa, wherein virulence of the Herboheal-unexposed daughter cultures, of the Herboheal-exposed parent culture, was also found to be attenuated.
Overall, this study indicates Herboheal formulation to be an effective antipathogenic preparation and validates its indicated traditional therapeutic use as a wound-care formulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patel, Pooja& Joshi, Chinmayi& Kothari, Vijay. 2019. Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-986289
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patel, Pooja…[et al.]. Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-986289
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patel, Pooja& Joshi, Chinmayi& Kothari, Vijay. Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-986289
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-986289
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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