Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line
المؤلفون المشاركون
Shiassi Arani, Faranak
Karimzadeh, Latifeh
Ghafoori, Seyed Mohammad
Nabiuni, Mohammad
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Honey bee venom (HBV) has various biological activities such as the inhibitory effect on several types of cancer.
Cisplatin is an old and potent drug to treat most of the cancers.
Our aim in the present study was to determine antimutagenic and cytotoxic effects of HBV on mammary carcinoma, exclusively and in combination with cisplatin.
Methods.
In this study, 4T1 cell line was cultured in RPMI-1640 with 10% fetal bovine serum (FBS), at 37°C in humidified CO2 incubator.
The cell viabilities were examined by the MTT assay.
Also, HBV was screened for its antimutagenic activity via the Ames test.
The results were assessed by SPSS software version 19 and one-way ANOVA method considering p<0.05 level of significance.
Results.
The results showed that 6 mg/ml of HBV, 20 μg/ml of cisplatin, and 6 mg/ml HBV with 10 μg/ml cisplatin could induce approximately 50% of 4T1 cell death.
The concentration 7 mg/ml of HBV with of 62.76% inhibitory rate showed the highest antimutagenic activity in comparison with other treatment groups.
Conclusions.
The MTT assay demonstrated that HBV and cisplatin could cause cell death in a dose-dependent manner.
The cytotoxic effect of cisplatin also promoted by HBV.
Ames test outcomes indicated that HBV could act as a significant mutagenic agent.
The antimutagenic activity of HBV was increased considerably in the presence of S9 mix.
Therefore, our findings have revealed that HBV can enhance the cytotoxic effect of cisplatin drug and its cancer-preventing effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shiassi Arani, Faranak& Karimzadeh, Latifeh& Ghafoori, Seyed Mohammad& Nabiuni, Mohammad. 2019. Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-986302
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shiassi Arani, Faranak…[et al.]. Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-986302
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shiassi Arani, Faranak& Karimzadeh, Latifeh& Ghafoori, Seyed Mohammad& Nabiuni, Mohammad. Antimutagenic and Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on 4T1 Invasive Mammary Carcinoma Cell Line. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-986302
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-986302
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر