Protein Alterations in Infiltrating Ductal Carcinomas of the Breast as Detected by Nonequilibrium pH Gradient Electrophoresis and Mass Spectrometry
المؤلفون المشاركون
Kabbage, Maria
Hoebeke, Johan
Remadi, Sami
Chouchane, Lotfi
Trimeche, Mounir
Guillier, Christelle Lemaitre
Hamrita, Bechr
Chahed, Karim
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-02-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Improvement of breast-cancer detection through the identification of potential cancer biomarkers is considered as a promising strategy for effective assessment of the disease.
The current study has used nonequilibrium pH gradient electrophoresis with subsequent analysis by mass spectrometry to identify protein alterations in invasive ductal carcinomas of the breast from Tunisian women.
We have identified multiple protein alterations in tumor tissues that were picked, processed, and unambiguously assigned identities by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF).
The proteins identified span a wide range of functions and are believed to have potential clinical applications as cancer biomarkers.
They include glycolytic enzymes, molecular chaperones, cytoskeletal-related proteins, antioxydant enzymes, and immunologic related proteins.
Among these proteins, enolase 1, phosphoglycerate kinase 1, deoxyhemoglobin, Mn-superoxyde dismutase, α-B-crystallin, HSP27, Raf kinase inhibitor protein, heterogeneous nuclear ribonucleoprotein A2/B1, cofilin 1, and peptidylprolyl isomerase A were overexpressed in tumors compared with normal tissues.
In contrast, the IGHG1 protein, the complement C3 component C3c, which are two newly identified protein markers, were downregulated in IDCA tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kabbage, Maria& Chahed, Karim& Hamrita, Bechr& Guillier, Christelle Lemaitre& Trimeche, Mounir& Remadi, Sami…[et al.]. 2008. Protein Alterations in Infiltrating Ductal Carcinomas of the Breast as Detected by Nonequilibrium pH Gradient Electrophoresis and Mass Spectrometry. BioMed Research International،Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-987788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kabbage, Maria…[et al.]. Protein Alterations in Infiltrating Ductal Carcinomas of the Breast as Detected by Nonequilibrium pH Gradient Electrophoresis and Mass Spectrometry. BioMed Research International No. 2008 (2008), pp.1-10.
https://search.emarefa.net/detail/BIM-987788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kabbage, Maria& Chahed, Karim& Hamrita, Bechr& Guillier, Christelle Lemaitre& Trimeche, Mounir& Remadi, Sami…[et al.]. Protein Alterations in Infiltrating Ductal Carcinomas of the Breast as Detected by Nonequilibrium pH Gradient Electrophoresis and Mass Spectrometry. BioMed Research International. 2008. Vol. 2008, no. 2008, pp.1-10.
https://search.emarefa.net/detail/BIM-987788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-987788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر