Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order

المؤلفون المشاركون

Min, Chan-Ki
Yang, Jae-Seong
Kim, Sanguk
Choi, Myung-Sik
Kim, Ik-Sang
Cho, Nam-Hyuk

المصدر

International Journal of Genomics

العدد

المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2008-03-27

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء

الملخص EN

Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium that belongs to the order of Rickettsiales.

Recently, we have reported that O.

tsutsugamushi has a unique genomic structure, consisting of highly repetitive sequences, and suggested that it may provide valuable insight into the evolution of intracellular bacteria.

Here, we have used genomic information to construct the major metabolic pathways of O.

tsutsugamushi and performed a comparative analysis of the metabolic genes and pathways of O.

tsutsugamushi with other members of the Rickettsiales order.

While O.

tsutsugamushi has the largest genome among the members of this order, mainly due to the presence of repeated sequences, its metabolic pathways have been highly streamlined.

Overall, the metabolic pathways of O.

tsutsugamushi were similar to Rickettsia but there were notable differences in several pathways including carbohydrate metabolism, the TCA cycle, and the synthesis of cell wall components as well as in the transport systems.

Our results will provide a useful guide to the postgenomic analysis of O.

tsutsugamushi and lead to a better understanding of the virulence and physiology of this intracellular pathogen.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Min, Chan-Ki& Yang, Jae-Seong& Kim, Sanguk& Choi, Myung-Sik& Kim, Ik-Sang& Cho, Nam-Hyuk. 2008. Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order. International Journal of Genomics،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-987874

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Min, Chan-Ki…[et al.]. Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order. International Journal of Genomics No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-987874

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Min, Chan-Ki& Yang, Jae-Seong& Kim, Sanguk& Choi, Myung-Sik& Kim, Ik-Sang& Cho, Nam-Hyuk. Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order. International Journal of Genomics. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-987874

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-987874