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Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order
Joint Authors
Min, Chan-Ki
Yang, Jae-Seong
Kim, Sanguk
Choi, Myung-Sik
Kim, Ik-Sang
Cho, Nam-Hyuk
Source
International Journal of Genomics
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium that belongs to the order of Rickettsiales.
Recently, we have reported that O.
tsutsugamushi has a unique genomic structure, consisting of highly repetitive sequences, and suggested that it may provide valuable insight into the evolution of intracellular bacteria.
Here, we have used genomic information to construct the major metabolic pathways of O.
tsutsugamushi and performed a comparative analysis of the metabolic genes and pathways of O.
tsutsugamushi with other members of the Rickettsiales order.
While O.
tsutsugamushi has the largest genome among the members of this order, mainly due to the presence of repeated sequences, its metabolic pathways have been highly streamlined.
Overall, the metabolic pathways of O.
tsutsugamushi were similar to Rickettsia but there were notable differences in several pathways including carbohydrate metabolism, the TCA cycle, and the synthesis of cell wall components as well as in the transport systems.
Our results will provide a useful guide to the postgenomic analysis of O.
tsutsugamushi and lead to a better understanding of the virulence and physiology of this intracellular pathogen.
American Psychological Association (APA)
Min, Chan-Ki& Yang, Jae-Seong& Kim, Sanguk& Choi, Myung-Sik& Kim, Ik-Sang& Cho, Nam-Hyuk. 2008. Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order. International Journal of Genomics،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-987874
Modern Language Association (MLA)
Min, Chan-Ki…[et al.]. Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order. International Journal of Genomics No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-987874
American Medical Association (AMA)
Min, Chan-Ki& Yang, Jae-Seong& Kim, Sanguk& Choi, Myung-Sik& Kim, Ik-Sang& Cho, Nam-Hyuk. Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order. International Journal of Genomics. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-987874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-987874