![](/images/graphics-bg.png)
Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine
المؤلفون المشاركون
Chen, Gang
Shi, Jixin
Hang, Chunhua
Hu, Zhigang
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-04-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Although N-acetylcysteine (NAC) has been shown to be neuroprotective for traumatic brain injury (TBI), the mechanisms for this beneficial effect are still poorly understood.
Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI.
However, it has not been investigated whether NAC modulates TBI-induced cerebral inflammatory response.
In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-κB) and inflammatory proteins such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1) after TBI.
As a result, we found that NF-κB, proinflammatory cytokines, and ICAM-1 were increased in all injured animals.
In animals given NAC post-TBI, NF-κB, IL-1β, TNF-α, and ICAM-1 were decreased in comparison to vehicle-treated animals.
Measures of IL-6 showed no change after NAC treatment.
NAC administration reduced brain edema, BBB permeability, and apoptotic index in the injured brain.
The results suggest that post-TBI NAC administration may attenuate inflammatory response in the injured rat brain, and this may be one mechanism by which NAC ameliorates secondary brain damage following TBI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Gang& Shi, Jixin& Hu, Zhigang& Hang, Chunhua. 2008. Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988149
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Gang…[et al.]. Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine. Mediators of Inflammation No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988149
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Gang& Shi, Jixin& Hu, Zhigang& Hang, Chunhua. Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988149
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988149
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)