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Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine
Joint Authors
Chen, Gang
Shi, Jixin
Hang, Chunhua
Hu, Zhigang
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although N-acetylcysteine (NAC) has been shown to be neuroprotective for traumatic brain injury (TBI), the mechanisms for this beneficial effect are still poorly understood.
Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI.
However, it has not been investigated whether NAC modulates TBI-induced cerebral inflammatory response.
In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-κB) and inflammatory proteins such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1) after TBI.
As a result, we found that NF-κB, proinflammatory cytokines, and ICAM-1 were increased in all injured animals.
In animals given NAC post-TBI, NF-κB, IL-1β, TNF-α, and ICAM-1 were decreased in comparison to vehicle-treated animals.
Measures of IL-6 showed no change after NAC treatment.
NAC administration reduced brain edema, BBB permeability, and apoptotic index in the injured brain.
The results suggest that post-TBI NAC administration may attenuate inflammatory response in the injured rat brain, and this may be one mechanism by which NAC ameliorates secondary brain damage following TBI.
American Psychological Association (APA)
Chen, Gang& Shi, Jixin& Hu, Zhigang& Hang, Chunhua. 2008. Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988149
Modern Language Association (MLA)
Chen, Gang…[et al.]. Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine. Mediators of Inflammation No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-988149
American Medical Association (AMA)
Chen, Gang& Shi, Jixin& Hu, Zhigang& Hang, Chunhua. Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-988149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988149