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Platelet Counts and Platelet Activation Markers in Obese Subjects
المؤلفون المشاركون
Shenkerman, Galina
Samocha-Bonet, Dorit
Saar, Nili
Abu-Abeid, Subchi
Berliner, Shlomo
Justo, Dan
Rogowski, Ori
Shapira, Itzhak
Tomer, Aaron
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-02-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals.
Methods and subjects.
A total of 6319 individuals participated in the study.
Complete blood counts, high sensitivity C-reactive protein (hs-CRP) serum levels, and body mass index (BMI) were measured during routine checkups.
Platelet activation markers were studied among 30 obese (BMI = 41 ± 8 kg/m2) and 35 nonobese (BMI = 24 ± 3 kg/m2) individuals.
Platelet activation status was evaluated by flow cytometry using specific antibodies against the activated platelet membrane glycoprotein IIb/IIIa, p-selectin (CD-62 p), and binding of Annexin-V to platelet anionic phospholipids.
Results.
Overweight, obese, and morbidly obese females had significantly elevated platelet counts (P<.0001) compared with normal-weight females.
No significant elevation of platelet counts was observed in the male subgroups.
A significant age adjusted correlation between BMI and platelet counts (P<.0001) was found among females.
This correlation was attenuated (P=.001) after adjustment for hs-CRP concentrations.
The flow cytometry analysis of platelets showed no significant differences in activation marker expression between nonobese and obese individuals.
Discussion.
Obesity may be associated with elevated platelet counts in females with chronic inflammation.
Obesity is not associated with increased platelet activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Samocha-Bonet, Dorit& Justo, Dan& Rogowski, Ori& Saar, Nili& Abu-Abeid, Subchi& Shenkerman, Galina…[et al.]. 2008. Platelet Counts and Platelet Activation Markers in Obese Subjects. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Samocha-Bonet, Dorit…[et al.]. Platelet Counts and Platelet Activation Markers in Obese Subjects. Mediators of Inflammation No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Samocha-Bonet, Dorit& Justo, Dan& Rogowski, Ori& Saar, Nili& Abu-Abeid, Subchi& Shenkerman, Galina…[et al.]. Platelet Counts and Platelet Activation Markers in Obese Subjects. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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