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Platelet Counts and Platelet Activation Markers in Obese Subjects
Joint Authors
Shenkerman, Galina
Samocha-Bonet, Dorit
Saar, Nili
Abu-Abeid, Subchi
Berliner, Shlomo
Justo, Dan
Rogowski, Ori
Shapira, Itzhak
Tomer, Aaron
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals.
Methods and subjects.
A total of 6319 individuals participated in the study.
Complete blood counts, high sensitivity C-reactive protein (hs-CRP) serum levels, and body mass index (BMI) were measured during routine checkups.
Platelet activation markers were studied among 30 obese (BMI = 41 ± 8 kg/m2) and 35 nonobese (BMI = 24 ± 3 kg/m2) individuals.
Platelet activation status was evaluated by flow cytometry using specific antibodies against the activated platelet membrane glycoprotein IIb/IIIa, p-selectin (CD-62 p), and binding of Annexin-V to platelet anionic phospholipids.
Results.
Overweight, obese, and morbidly obese females had significantly elevated platelet counts (P<.0001) compared with normal-weight females.
No significant elevation of platelet counts was observed in the male subgroups.
A significant age adjusted correlation between BMI and platelet counts (P<.0001) was found among females.
This correlation was attenuated (P=.001) after adjustment for hs-CRP concentrations.
The flow cytometry analysis of platelets showed no significant differences in activation marker expression between nonobese and obese individuals.
Discussion.
Obesity may be associated with elevated platelet counts in females with chronic inflammation.
Obesity is not associated with increased platelet activation.
American Psychological Association (APA)
Samocha-Bonet, Dorit& Justo, Dan& Rogowski, Ori& Saar, Nili& Abu-Abeid, Subchi& Shenkerman, Galina…[et al.]. 2008. Platelet Counts and Platelet Activation Markers in Obese Subjects. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988151
Modern Language Association (MLA)
Samocha-Bonet, Dorit…[et al.]. Platelet Counts and Platelet Activation Markers in Obese Subjects. Mediators of Inflammation No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-988151
American Medical Association (AMA)
Samocha-Bonet, Dorit& Justo, Dan& Rogowski, Ori& Saar, Nili& Abu-Abeid, Subchi& Shenkerman, Galina…[et al.]. Platelet Counts and Platelet Activation Markers in Obese Subjects. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-988151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988151