Peroxisome Proliferators-Activated Receptor (PPAR)‎ Modulators and Metabolic Disorders

المؤلفون المشاركون

Lee, Kyoung
Cho, Min-Chul
Yoon, Do-young
Paik, Sang-Gi

المصدر

PPAR Research

العدد

المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2008-03-09

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء

الملخص EN

Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension.

Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed.

Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs to the nuclear receptor superfamily, has many beneficial clinical effects.

PPAR directly modulates gene expression by binding to a specific ligand.

All PPAR subtypes (α,γ, and σ) are involved in glucose metabolism, lipid metabolism, and energy balance.

PPAR agonists play an important role in therapeutic aspects of metabolic disorders.

However, undesired effects of the existing PPAR agonists have been reported.

A great deal of recent research has focused on the discovery of new PPAR modulators with more beneficial effects and more safety without producing undesired side effects.

Herein, we briefly review the roles of PPAR in metabolic disorders, the effects of PPAR modulators in metabolic disorders, and the technologies with which to discover new PPAR modulators.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cho, Min-Chul& Lee, Kyoung& Paik, Sang-Gi& Yoon, Do-young. 2008. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Research،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988229

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cho, Min-Chul…[et al.]. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Research No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-988229

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cho, Min-Chul& Lee, Kyoung& Paik, Sang-Gi& Yoon, Do-young. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988229

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-988229