Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders
Joint Authors
Lee, Kyoung
Cho, Min-Chul
Yoon, Do-young
Paik, Sang-Gi
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension.
Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed.
Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs to the nuclear receptor superfamily, has many beneficial clinical effects.
PPAR directly modulates gene expression by binding to a specific ligand.
All PPAR subtypes (α,γ, and σ) are involved in glucose metabolism, lipid metabolism, and energy balance.
PPAR agonists play an important role in therapeutic aspects of metabolic disorders.
However, undesired effects of the existing PPAR agonists have been reported.
A great deal of recent research has focused on the discovery of new PPAR modulators with more beneficial effects and more safety without producing undesired side effects.
Herein, we briefly review the roles of PPAR in metabolic disorders, the effects of PPAR modulators in metabolic disorders, and the technologies with which to discover new PPAR modulators.
American Psychological Association (APA)
Cho, Min-Chul& Lee, Kyoung& Paik, Sang-Gi& Yoon, Do-young. 2008. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Research،Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988229
Modern Language Association (MLA)
Cho, Min-Chul…[et al.]. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Research No. 2008 (2008), pp.1-14.
https://search.emarefa.net/detail/BIM-988229
American Medical Association (AMA)
Cho, Min-Chul& Lee, Kyoung& Paik, Sang-Gi& Yoon, Do-young. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-14.
https://search.emarefa.net/detail/BIM-988229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988229