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Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development
المؤلفون المشاركون
Scipioni, Angela
Stefanini, Stefania
Giorgi, Mauro
Nuccetelli, Valeria
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-08-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In mammalian lung, at the transition to extrauterine life, NO/cGMP signal transduction system is known to play crucial roles in the regulation of vascular resistance and is supposed to act in angiogenesis.
PDE5, which is the most abundant cGMP metabolizing enzyme within the lung, is highly expressed in the perinatal period, but its localisation in the different pulmonary cells is still poorly known.
In our research, PDE5 immunohistochemical distribution was investigated in foetal and neonatal rat lung.
The highest expression of PDE5 was found in cells randomly located in the stroma; in newborns, in particular, many cells in the intersaccular walls were heavily labelled, while much lower staining levels were shown by smooth myocytes belonging to vessels and airways.
On the basis of their immunoreactivity for α-SM actin and/or desmin, most of the heavily PDE5-positive cells were identified as interstitial myofibroblasts and transitional pericytes, while only a few were interpreted as interstitial lipofibroblasts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scipioni, Angela& Giorgi, Mauro& Nuccetelli, Valeria& Stefanini, Stefania. 2009. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development. BioMed Research International،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988484
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scipioni, Angela…[et al.]. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development. BioMed Research International No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-988484
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scipioni, Angela& Giorgi, Mauro& Nuccetelli, Valeria& Stefanini, Stefania. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988484
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988484
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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