Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development
Joint Authors
Scipioni, Angela
Stefanini, Stefania
Giorgi, Mauro
Nuccetelli, Valeria
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In mammalian lung, at the transition to extrauterine life, NO/cGMP signal transduction system is known to play crucial roles in the regulation of vascular resistance and is supposed to act in angiogenesis.
PDE5, which is the most abundant cGMP metabolizing enzyme within the lung, is highly expressed in the perinatal period, but its localisation in the different pulmonary cells is still poorly known.
In our research, PDE5 immunohistochemical distribution was investigated in foetal and neonatal rat lung.
The highest expression of PDE5 was found in cells randomly located in the stroma; in newborns, in particular, many cells in the intersaccular walls were heavily labelled, while much lower staining levels were shown by smooth myocytes belonging to vessels and airways.
On the basis of their immunoreactivity for α-SM actin and/or desmin, most of the heavily PDE5-positive cells were identified as interstitial myofibroblasts and transitional pericytes, while only a few were interpreted as interstitial lipofibroblasts.
American Psychological Association (APA)
Scipioni, Angela& Giorgi, Mauro& Nuccetelli, Valeria& Stefanini, Stefania. 2009. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development. BioMed Research International،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988484
Modern Language Association (MLA)
Scipioni, Angela…[et al.]. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development. BioMed Research International No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-988484
American Medical Association (AMA)
Scipioni, Angela& Giorgi, Mauro& Nuccetelli, Valeria& Stefanini, Stefania. Immunohistochemical Localisation of PDE5 in Rat Lung during Pre- and Postnatal Development. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988484