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Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy
المؤلفون المشاركون
Mosseri, Véronique
Asselain, Bernard
des Guetz, Gaetan
Chapelier, Alain
Pouillart, Pierre
Dorval, Thierry
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-09-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
An analysis of the clinicopathologic features and treatment of patients was performed to guide evaluation and management of postirradiation sarcoma.
Patients and Methods.
Between 1994 and 2001, 25 patients with postirradiation sarcoma were treated in one center with different chemotherapy, mainly in neoadjuvant setting (19).
Tumors for which these patients received radiotherapy initially were mainly breast carcinoma (for 15 patients).
The postirradiation sarcomas were of different histopathologic forms, most frequently osteosarcoma, leiomyosarcoma, and angiosarcoma.
Results.
Of the 25 patients, 19 were initially treated with chemotherapy.
Nine of 19 pretreated patients achieved clinical partial response (RP = 47%).
Leiomyosarcomas were good responders (3/4) and undifferentiated sarcoma (3/5).
Responders were more often treated with MAID (6/8).
Eight of the 9 responders underwent surgery.
Two patients achieved complete histological response.
Seven of the 9 good responders are alive with a median follow up of 24 months.
For all treated patients, median follow up 24 months (6–84 months), overall survival and disease free survival were, respectively, 17/25 (68%), and 14/25 (56%).
Conclusion.
From our data, postirradiation sarcoma should not be managed differently from primary sarcoma.
Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
des Guetz, Gaetan& Chapelier, Alain& Mosseri, Véronique& Dorval, Thierry& Asselain, Bernard& Pouillart, Pierre. 2009. Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy. Complexity،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988655
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
des Guetz, Gaetan…[et al.]. Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy. Complexity No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-988655
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
des Guetz, Gaetan& Chapelier, Alain& Mosseri, Véronique& Dorval, Thierry& Asselain, Bernard& Pouillart, Pierre. Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy. Complexity. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988655
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988655
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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