Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy
Joint Authors
Mosseri, Véronique
Asselain, Bernard
des Guetz, Gaetan
Chapelier, Alain
Pouillart, Pierre
Dorval, Thierry
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
An analysis of the clinicopathologic features and treatment of patients was performed to guide evaluation and management of postirradiation sarcoma.
Patients and Methods.
Between 1994 and 2001, 25 patients with postirradiation sarcoma were treated in one center with different chemotherapy, mainly in neoadjuvant setting (19).
Tumors for which these patients received radiotherapy initially were mainly breast carcinoma (for 15 patients).
The postirradiation sarcomas were of different histopathologic forms, most frequently osteosarcoma, leiomyosarcoma, and angiosarcoma.
Results.
Of the 25 patients, 19 were initially treated with chemotherapy.
Nine of 19 pretreated patients achieved clinical partial response (RP = 47%).
Leiomyosarcomas were good responders (3/4) and undifferentiated sarcoma (3/5).
Responders were more often treated with MAID (6/8).
Eight of the 9 responders underwent surgery.
Two patients achieved complete histological response.
Seven of the 9 good responders are alive with a median follow up of 24 months.
For all treated patients, median follow up 24 months (6–84 months), overall survival and disease free survival were, respectively, 17/25 (68%), and 14/25 (56%).
Conclusion.
From our data, postirradiation sarcoma should not be managed differently from primary sarcoma.
Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies.
American Psychological Association (APA)
des Guetz, Gaetan& Chapelier, Alain& Mosseri, Véronique& Dorval, Thierry& Asselain, Bernard& Pouillart, Pierre. 2009. Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy. Complexity،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988655
Modern Language Association (MLA)
des Guetz, Gaetan…[et al.]. Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy. Complexity No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-988655
American Medical Association (AMA)
des Guetz, Gaetan& Chapelier, Alain& Mosseri, Véronique& Dorval, Thierry& Asselain, Bernard& Pouillart, Pierre. Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy. Complexity. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988655