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Development of a Novel Bioinformatics Tool for In Silico Validation of Protein Interactions
المؤلفون المشاركون
Comincini, Sergio
Azzalin, Alberto
Bellazzi, Riccardo
Barbarini, Nicola
Simonelli, Luca
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-05-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Protein interactions are crucial in most biological processes.
Several in silico methods have been recently developed to predict them.
This paper describes a bioinformatics method that combines sequence similarity and structural information to support experimental studies on protein interactions.
Given a target protein, the approach selects the most likely interactors among the candidates revealed by experimental techniques, but not yet in vivo validated.
The sequence and the structural information of the in vivo confirmed proteins and complexes are exploited to evaluate the candidate interactors.
Finally, a score is calculated to suggest the most likely interactors of the target protein.
As an example, we searched for GRB2 interactors.
We ranked a set of 46 candidate interactors by the presented method.
These candidates were then reduced to 21, through a score threshold chosen by means of a cross-validation strategy.
Among them, the isoform 1 of MAPK14 was in silico confirmed as a GRB2 interactor.
Finally, given a set of already confirmed interactors of GRB2, the accuracy and the precision of the approach were 75% and 86%, respectively.
In conclusion, the proposed method can be conveniently exploited to select the proteins to be experimentally investigated within a set of potential interactors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barbarini, Nicola& Simonelli, Luca& Azzalin, Alberto& Comincini, Sergio& Bellazzi, Riccardo. 2010. Development of a Novel Bioinformatics Tool for In Silico Validation of Protein Interactions. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barbarini, Nicola…[et al.]. Development of a Novel Bioinformatics Tool for In Silico Validation of Protein Interactions. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barbarini, Nicola& Simonelli, Luca& Azzalin, Alberto& Comincini, Sergio& Bellazzi, Riccardo. Development of a Novel Bioinformatics Tool for In Silico Validation of Protein Interactions. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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