Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning
المؤلفون المشاركون
Hassan, Moustapha
Rozell, Bjorn
Hassan, Zuzana
al-Hashmi, Suleiman
Concha, Hernan
Lundmark, Carin
Grönvik, Kjell-Olov
Abedi-Valugerdi, Manuchehr
Sadeghi, Behnam
المصدر
Journal of Immunology Research
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-11-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT).
BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6.
Control group consisted of syngeneic transplanted Balb/c mice.
In allogeneic settings, significant expansion and maturation of donor dendritic cells (DCs) were observed at day +3, while donor T-cells CD8+ were increased at day +5 (230%) compared to syngeneic HSCT.
Highest levels of inflammatory cytokines IL-2, IFN-gamma, and TNF-alfa at day +5 matched T-cell activation.
Concomitantly naïve T-cells gain effecr-memory phenotype and migrated from spleen to peripheral lymphoid organs.
Thus, in the very early phase of GHVD following Bu-Cy conditioning donor, DCs play an important role in the activation of donor T cells.
Subsequently, donor naïve T-cells gain effector-memory phenotype and initiate GVHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sadeghi, Behnam& al-Hashmi, Suleiman& Hassan, Zuzana& Rozell, Bjorn& Concha, Hernan& Lundmark, Carin…[et al.]. 2010. Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989286
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sadeghi, Behnam…[et al.]. Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning. Journal of Immunology Research No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-989286
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sadeghi, Behnam& al-Hashmi, Suleiman& Hassan, Zuzana& Rozell, Bjorn& Concha, Hernan& Lundmark, Carin…[et al.]. Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-989286
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989286
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر