Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases

المؤلفون المشاركون

Kobayashi, Tsutomu
Shiomi, Masashi
Ito, Takashi

المصدر

BioMed Research International

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-03-23

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Conquering cardiovascular diseases is one of the most important problems in human health.

To overcome cardiovascular diseases, animal models have played important roles.

Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way.

In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function.

On the other hand, since lipoprotein metabolism and atherosclerotic lesions in rabbits closely resemble those in humans, several useful animal models for these diseases have been developed in rabbits.

One of the most famous of these is the Watanabe heritable hyperlipidemic (WHHL) rabbit, which develops hypercholesterolemia and atherosclerosis spontaneously due to genetic and functional deficiencies of the low-density lipoprotein (LDL) receptor.

The WHHL rabbit has been improved to develop myocardial infarction, and the new strain was designated the myocardial infarction-prone WHHL (WHHLMI) rabbit.

This review summarizes the importance of selecting animal species for translational research in biomedical science, the development of WHHL and WHHLMI rabbits, their application to the development of hypocholesterolemic and/or antiatherosclerotic drugs, and future prospects regarding WHHL and WHHLMI rabbits.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kobayashi, Tsutomu& Ito, Takashi& Shiomi, Masashi. 2011. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990078

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kobayashi, Tsutomu…[et al.]. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990078

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kobayashi, Tsutomu& Ito, Takashi& Shiomi, Masashi. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990078

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-990078