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Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases
Joint Authors
Kobayashi, Tsutomu
Shiomi, Masashi
Ito, Takashi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Conquering cardiovascular diseases is one of the most important problems in human health.
To overcome cardiovascular diseases, animal models have played important roles.
Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way.
In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function.
On the other hand, since lipoprotein metabolism and atherosclerotic lesions in rabbits closely resemble those in humans, several useful animal models for these diseases have been developed in rabbits.
One of the most famous of these is the Watanabe heritable hyperlipidemic (WHHL) rabbit, which develops hypercholesterolemia and atherosclerosis spontaneously due to genetic and functional deficiencies of the low-density lipoprotein (LDL) receptor.
The WHHL rabbit has been improved to develop myocardial infarction, and the new strain was designated the myocardial infarction-prone WHHL (WHHLMI) rabbit.
This review summarizes the importance of selecting animal species for translational research in biomedical science, the development of WHHL and WHHLMI rabbits, their application to the development of hypocholesterolemic and/or antiatherosclerotic drugs, and future prospects regarding WHHL and WHHLMI rabbits.
American Psychological Association (APA)
Kobayashi, Tsutomu& Ito, Takashi& Shiomi, Masashi. 2011. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. BioMed Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990078
Modern Language Association (MLA)
Kobayashi, Tsutomu…[et al.]. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. BioMed Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-990078
American Medical Association (AMA)
Kobayashi, Tsutomu& Ito, Takashi& Shiomi, Masashi. Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-990078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990078