Colocalization of Serum Amyloid A with Microtubules in Human Coronary Artery Endothelial Cells
المؤلفون المشاركون
Resnik, Nataša
Mrak-Poljšak, Katjuša
Veranič, Peter
Lakota, Katja
Sodin-Semrl, Snezna
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Serum amyloid A (SAA) acts as a major acute phase protein and represents a sensitive and accurate marker of inflammation.
Besides its hepatic origin, as the main source of serum SAA, this protein is also produced extrahepatically.
The mRNA levels of SAA become significantly elevated following proinflammatory stimuli, as well as, are induced through their own positive feedback in human primary coronary artery endothelial cells.
However, the intracellular functions of SAA are so far unknown.
Colocalization of SAA with cytoskeletal filaments has previously been proposed, so we analyzed the colocalization of SAA with all three cytoskeletal elements: actin filaments, vimentin filaments, and microtubules.
Immunofluorescent double-labeling analyses confirmed by PLA method revealed a strict colocalization of SAA with microtubules and a very infrequent attachment to vimentin while the distribution of actin filaments appeared clearly separated from SAA staining.
Also, no significant colocalization was found between SAA and endomembranes labeled with the fluorescent lipid stain DiO6.
However, SAA appears to be located also unbound in the cytosol, as well as inside the nucleus and within nanotubes extending from the cells or bridging neighboring cells.
These different locations of SAA in endothelial cells strongly indicate multiple potential functions of this protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lakota, Katja& Resnik, Nataša& Mrak-Poljšak, Katjuša& Sodin-Semrl, Snezna& Veranič, Peter. 2011. Colocalization of Serum Amyloid A with Microtubules in Human Coronary Artery Endothelial Cells. BioMed Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990181
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lakota, Katja…[et al.]. Colocalization of Serum Amyloid A with Microtubules in Human Coronary Artery Endothelial Cells. BioMed Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-990181
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lakota, Katja& Resnik, Nataša& Mrak-Poljšak, Katjuša& Sodin-Semrl, Snezna& Veranič, Peter. Colocalization of Serum Amyloid A with Microtubules in Human Coronary Artery Endothelial Cells. BioMed Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-990181
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990181
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر