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Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
المؤلفون المشاركون
Ramírez, Marco A.
Leiva, Andrea
Pardo, Fabián
Sobrevia, Luis
Farías, Marcelo
Casanello, Paola
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-24
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Gestational diabetes mellitus (GDM) and obesity in pregnancy (OP) are pathological conditions associated with placenta vascular dysfunction coursing with metabolic changes at the fetoplacental microvascular and macrovascular endothelium.
These alterations are seen as abnormal expression and activity of the cationic amino acid transporters and endothelial nitric oxide synthase isoform, that is, the “endothelial L-arginine/nitric oxide signalling pathway.” Several studies suggest that the endogenous nucleoside adenosine along with insulin, and potentially arginases, are factors involved in GDM-, but much less information regards their role in OP-associated placental vascular alterations.
There is convincing evidence that GDM and OP prone placental endothelium to an “altered metabolic state” leading to fetal programming evidenced at birth, a phenomenon associated with future development of chronic diseases.
In this paper it is suggested that this pathological state could be considered as a metabolic marker that could predict occurrence of diseases in adulthood, such as cardiovascular disease, obesity, diabetes mellitus (including gestational diabetes), and metabolic syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leiva, Andrea& Pardo, Fabián& Ramírez, Marco A.& Farías, Marcelo& Casanello, Paola& Sobrevia, Luis. 2011. Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-990630
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leiva, Andrea…[et al.]. Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy. Journal of Diabetes Research No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-990630
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leiva, Andrea& Pardo, Fabián& Ramírez, Marco A.& Farías, Marcelo& Casanello, Paola& Sobrevia, Luis. Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-990630
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990630
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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