Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
Joint Authors
Ramírez, Marco A.
Leiva, Andrea
Pardo, Fabián
Sobrevia, Luis
Farías, Marcelo
Casanello, Paola
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Gestational diabetes mellitus (GDM) and obesity in pregnancy (OP) are pathological conditions associated with placenta vascular dysfunction coursing with metabolic changes at the fetoplacental microvascular and macrovascular endothelium.
These alterations are seen as abnormal expression and activity of the cationic amino acid transporters and endothelial nitric oxide synthase isoform, that is, the “endothelial L-arginine/nitric oxide signalling pathway.” Several studies suggest that the endogenous nucleoside adenosine along with insulin, and potentially arginases, are factors involved in GDM-, but much less information regards their role in OP-associated placental vascular alterations.
There is convincing evidence that GDM and OP prone placental endothelium to an “altered metabolic state” leading to fetal programming evidenced at birth, a phenomenon associated with future development of chronic diseases.
In this paper it is suggested that this pathological state could be considered as a metabolic marker that could predict occurrence of diseases in adulthood, such as cardiovascular disease, obesity, diabetes mellitus (including gestational diabetes), and metabolic syndrome.
American Psychological Association (APA)
Leiva, Andrea& Pardo, Fabián& Ramírez, Marco A.& Farías, Marcelo& Casanello, Paola& Sobrevia, Luis. 2011. Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy. Journal of Diabetes Research،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-990630
Modern Language Association (MLA)
Leiva, Andrea…[et al.]. Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy. Journal of Diabetes Research No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-990630
American Medical Association (AMA)
Leiva, Andrea& Pardo, Fabián& Ramírez, Marco A.& Farías, Marcelo& Casanello, Paola& Sobrevia, Luis. Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy. Journal of Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-990630
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990630