Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients

المؤلفون المشاركون

Moraes, Júlio C. B.
Saad, Carla Gonçalves
Bonfá, Eloísa
Mota, Licia Maria H.
Medeiros, Ana Claudia D.
Aikawa, Nádia E.
Silva, Clovis A. A.
Castro, Karla R.
De Carvalho, Jozélio Freire

المصدر

Journal of Immunology Research

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-07-24

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأحياء

الملخص EN

|Objectives.

To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA).

Methods.

Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included.

None had dyslipoproteinemia or previous statin use.

Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated.

Results.

The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8±49.7 versus 140.1±64.1 mg/dL, P=0.028) and VLDL-c (23.6±10.5 versus 28.4±13.7 mg/dL, P=0.019) levels.

In contrast, there were no differences in the mean TC (P=0.28), LDL-c (P=0.42), and HDL-c (P=0.26) levels.

Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05).

Positive correlations were found between VLDL-c and CRP (r=0.647, P=0.009) and between triglycerides and CRP (r=0.604, P=0.017) levels at 3M.

ESR reduction was observed after 3M (P=0.04).

Mean prednisone dose remained stable at beginning and at 3M (P=0.37).

Conclusion.

This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Castro, Karla R.& Aikawa, Nádia E.& Saad, Carla Gonçalves& Moraes, Júlio C. B.& Medeiros, Ana Claudia D.& Mota, Licia Maria H.…[et al.]. 2011. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990764

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Castro, Karla R.…[et al.]. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-990764

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Castro, Karla R.& Aikawa, Nádia E.& Saad, Carla Gonçalves& Moraes, Júlio C. B.& Medeiros, Ana Claudia D.& Mota, Licia Maria H.…[et al.]. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990764

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-990764