Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients
Joint Authors
Moraes, Júlio C. B.
Saad, Carla Gonçalves
Bonfá, Eloísa
Mota, Licia Maria H.
Medeiros, Ana Claudia D.
Aikawa, Nádia E.
Silva, Clovis A. A.
Castro, Karla R.
De Carvalho, Jozélio Freire
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
|Objectives.
To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic arthritis (PsA).
Methods.
Fifteen PsA patients (eight polyarticular, four oligoarticular, two axial, and one mutilating) under infliximab were included.
None had dyslipoproteinemia or previous statin use.
Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated.
Results.
The comparisons of lipid levels between baseline and after three months (3M) of anti-TNF therapy showed that there was a significant increase in mean triglycerides (117.8±49.7 versus 140.1±64.1 mg/dL, P=0.028) and VLDL-c (23.6±10.5 versus 28.4±13.7 mg/dL, P=0.019) levels.
In contrast, there were no differences in the mean TC (P=0.28), LDL-c (P=0.42), and HDL-c (P=0.26) levels.
Analysis of the frequencies of each lipid alteration at baseline and at 3M were alike (P>0.05).
Positive correlations were found between VLDL-c and CRP (r=0.647, P=0.009) and between triglycerides and CRP (r=0.604, P=0.017) levels at 3M.
ESR reduction was observed after 3M (P=0.04).
Mean prednisone dose remained stable at beginning and at 3M (P=0.37).
Conclusion.
This study demonstrated that anti-TNF may increase TG and VLDL-c levels in PsA patients after three months.
American Psychological Association (APA)
Castro, Karla R.& Aikawa, Nádia E.& Saad, Carla Gonçalves& Moraes, Júlio C. B.& Medeiros, Ana Claudia D.& Mota, Licia Maria H.…[et al.]. 2011. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990764
Modern Language Association (MLA)
Castro, Karla R.…[et al.]. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-990764
American Medical Association (AMA)
Castro, Karla R.& Aikawa, Nádia E.& Saad, Carla Gonçalves& Moraes, Júlio C. B.& Medeiros, Ana Claudia D.& Mota, Licia Maria H.…[et al.]. Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-990764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990764