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Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis
المؤلفون المشاركون
Oliveira, Manuel
Bosco, Nabil
Perruisseau, Genevieve
Nicolas, Jeanne
Segura-Roggero, Iris
Duboux, Stéphane
Briand, Muriel
Blum, Stéphanie
Benyacoub, Jalil
المصدر
Journal of Immunology Research
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Studies showed that specific probiotics provide therapeutic benefits in inflammatory bowel disease.
In vitro evidence suggested that Lactobacillus paracasei also called ST11 (CNCM I-2116) is a potent strain with immune modulation properties.
However, little is known about its capacity to alleviate inflammatory symptoms in vivo In this context, the main objective of this study was to investigate the role of ST11 on intestinal inflammation using the adoptive transfer mouse model of experimental colitis.
Rag2-/- recipient mice were fed with ST11 (109 CFU/day)a month prior toinduce colitis by adoptive transfer of naive T cells.
One month later, in clear contrast to nonfed mice, weight loss was significantly reduced by 50% in ST11-fed mice.
Further analysis of colon specimens revealed a significant reduction neutrophil infiltration and mucosal expression of IL1β, IL-6, and IL12 proinflammatory cytokines, whereas no consistent differences in expression of antibacterial peptides or tight junction proteins were observed between PBS and ST11-fed mice.
All together, our results demonstrate that oral administration of ST11 was safe and had a significant preventive effect on colitis.
We conclude that probiotics such as Lactobacillus paracasei harbor worthwhile in vivo immunomodulatory properties to prevent intestinal inflammation by nutritional approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Manuel& Bosco, Nabil& Perruisseau, Genevieve& Nicolas, Jeanne& Segura-Roggero, Iris& Duboux, Stéphane…[et al.]. 2011. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Manuel…[et al.]. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-990863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Manuel& Bosco, Nabil& Perruisseau, Genevieve& Nicolas, Jeanne& Segura-Roggero, Iris& Duboux, Stéphane…[et al.]. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-990863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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