Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis

Joint Authors

Oliveira, Manuel
Bosco, Nabil
Perruisseau, Genevieve
Nicolas, Jeanne
Segura-Roggero, Iris
Duboux, Stéphane
Briand, Muriel
Blum, Stéphanie
Benyacoub, Jalil

Source

Journal of Immunology Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-06-13

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Biology

Abstract EN

Studies showed that specific probiotics provide therapeutic benefits in inflammatory bowel disease.

In vitro evidence suggested that Lactobacillus paracasei also called ST11 (CNCM I-2116) is a potent strain with immune modulation properties.

However, little is known about its capacity to alleviate inflammatory symptoms in vivo In this context, the main objective of this study was to investigate the role of ST11 on intestinal inflammation using the adoptive transfer mouse model of experimental colitis.

Rag2-/- recipient mice were fed with ST11 (109 CFU/day)a month prior toinduce colitis by adoptive transfer of naive T cells.

One month later, in clear contrast to nonfed mice, weight loss was significantly reduced by 50% in ST11-fed mice.

Further analysis of colon specimens revealed a significant reduction neutrophil infiltration and mucosal expression of IL1β, IL-6, and IL12 proinflammatory cytokines, whereas no consistent differences in expression of antibacterial peptides or tight junction proteins were observed between PBS and ST11-fed mice.

All together, our results demonstrate that oral administration of ST11 was safe and had a significant preventive effect on colitis.

We conclude that probiotics such as Lactobacillus paracasei harbor worthwhile in vivo immunomodulatory properties to prevent intestinal inflammation by nutritional approaches.

American Psychological Association (APA)

Oliveira, Manuel& Bosco, Nabil& Perruisseau, Genevieve& Nicolas, Jeanne& Segura-Roggero, Iris& Duboux, Stéphane…[et al.]. 2011. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990863

Modern Language Association (MLA)

Oliveira, Manuel…[et al.]. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-990863

American Medical Association (AMA)

Oliveira, Manuel& Bosco, Nabil& Perruisseau, Genevieve& Nicolas, Jeanne& Segura-Roggero, Iris& Duboux, Stéphane…[et al.]. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990863

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-990863