Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis
Joint Authors
Oliveira, Manuel
Bosco, Nabil
Perruisseau, Genevieve
Nicolas, Jeanne
Segura-Roggero, Iris
Duboux, Stéphane
Briand, Muriel
Blum, Stéphanie
Benyacoub, Jalil
Source
Journal of Immunology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Studies showed that specific probiotics provide therapeutic benefits in inflammatory bowel disease.
In vitro evidence suggested that Lactobacillus paracasei also called ST11 (CNCM I-2116) is a potent strain with immune modulation properties.
However, little is known about its capacity to alleviate inflammatory symptoms in vivo In this context, the main objective of this study was to investigate the role of ST11 on intestinal inflammation using the adoptive transfer mouse model of experimental colitis.
Rag2-/- recipient mice were fed with ST11 (109 CFU/day)a month prior toinduce colitis by adoptive transfer of naive T cells.
One month later, in clear contrast to nonfed mice, weight loss was significantly reduced by 50% in ST11-fed mice.
Further analysis of colon specimens revealed a significant reduction neutrophil infiltration and mucosal expression of IL1β, IL-6, and IL12 proinflammatory cytokines, whereas no consistent differences in expression of antibacterial peptides or tight junction proteins were observed between PBS and ST11-fed mice.
All together, our results demonstrate that oral administration of ST11 was safe and had a significant preventive effect on colitis.
We conclude that probiotics such as Lactobacillus paracasei harbor worthwhile in vivo immunomodulatory properties to prevent intestinal inflammation by nutritional approaches.
American Psychological Association (APA)
Oliveira, Manuel& Bosco, Nabil& Perruisseau, Genevieve& Nicolas, Jeanne& Segura-Roggero, Iris& Duboux, Stéphane…[et al.]. 2011. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990863
Modern Language Association (MLA)
Oliveira, Manuel…[et al.]. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research Vol. 2011, no. 2011 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-990863
American Medical Association (AMA)
Oliveira, Manuel& Bosco, Nabil& Perruisseau, Genevieve& Nicolas, Jeanne& Segura-Roggero, Iris& Duboux, Stéphane…[et al.]. Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis. Journal of Immunology Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-990863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-990863