Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations
المؤلفون المشاركون
Judson, Ian R.
Martins, Ana Sofia
Alam, Salma
Jones, Robin L.
Olmos, David
Scurr, Michelle
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-17
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Ewing's sarcoma family of tumours comprises a group of very aggressive diseases that are potentially curable with multimodality treatment.
Despite the undoubted success of current treatment, approximately 30% of patients will relapse and ultimately die of disease.
The insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the genesis, growth, proliferation, and the development of metastatic disease in Ewing's sarcoma.
In addition, IGF1-R has been validated, both in vitro and in vivo, as a potential therapeutic target in Ewing's sarcoma.
Phase I studies of IGF-1R monoclonal antibodies reported several radiological and clinical responses in Ewing's sarcoma patients, and initial reports of several Phase II studies suggest that about a fourth of the patients would benefit from IGF-1R monoclonal antibodies as single therapy, with approximately 10% of patients achieving objective responses.
Furthermore, these therapies are well tolerated, and thus far severe toxicity has been rare.
Other studies assessing IGF-1R monoclonal antibodies in combination with traditional cytotoxics or other targeted therapies are expected.
Despite, the initial promising results, not all patients benefit from IGF-1R inhibition, and consequently, there is an urgent need for the identification of predictive markers of response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olmos, David& Martins, Ana Sofia& Jones, Robin L.& Alam, Salma& Scurr, Michelle& Judson, Ian R.. 2011. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Complexity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991171
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olmos, David…[et al.]. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Complexity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-991171
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olmos, David& Martins, Ana Sofia& Jones, Robin L.& Alam, Salma& Scurr, Michelle& Judson, Ian R.. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Complexity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991171
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991171
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر