Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations
Joint Authors
Judson, Ian R.
Martins, Ana Sofia
Alam, Salma
Jones, Robin L.
Olmos, David
Scurr, Michelle
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ewing's sarcoma family of tumours comprises a group of very aggressive diseases that are potentially curable with multimodality treatment.
Despite the undoubted success of current treatment, approximately 30% of patients will relapse and ultimately die of disease.
The insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the genesis, growth, proliferation, and the development of metastatic disease in Ewing's sarcoma.
In addition, IGF1-R has been validated, both in vitro and in vivo, as a potential therapeutic target in Ewing's sarcoma.
Phase I studies of IGF-1R monoclonal antibodies reported several radiological and clinical responses in Ewing's sarcoma patients, and initial reports of several Phase II studies suggest that about a fourth of the patients would benefit from IGF-1R monoclonal antibodies as single therapy, with approximately 10% of patients achieving objective responses.
Furthermore, these therapies are well tolerated, and thus far severe toxicity has been rare.
Other studies assessing IGF-1R monoclonal antibodies in combination with traditional cytotoxics or other targeted therapies are expected.
Despite, the initial promising results, not all patients benefit from IGF-1R inhibition, and consequently, there is an urgent need for the identification of predictive markers of response.
American Psychological Association (APA)
Olmos, David& Martins, Ana Sofia& Jones, Robin L.& Alam, Salma& Scurr, Michelle& Judson, Ian R.. 2011. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Complexity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991171
Modern Language Association (MLA)
Olmos, David…[et al.]. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Complexity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-991171
American Medical Association (AMA)
Olmos, David& Martins, Ana Sofia& Jones, Robin L.& Alam, Salma& Scurr, Michelle& Judson, Ian R.. Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations. Complexity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-991171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991171