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Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex
المؤلفون المشاركون
Yang, Chun
Zhou, Zhi-Qiang
Gao, Zhi-Qin
Li, Wen-Yuan
Yu, Hai-Yin
Liu, Xiang-Liu
Yang, Jian-Jun
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Several lines of evidence have demonstrated that acute administration of ketamine elicits fast-acting antidepressant effects.
Moreover, tramadol also has potential antidepressant effects.
The aim of this study was to investigate the effects of pretreatment with tramadol on ketamine-induced antidepressant activity and was to determine the expression of mammalian target of rapamycin (mTOR) in rat hippocampus and prefrontal cortex.
Rats were intraperitoneally administrated with ketamine at the dose of 10 mg/kg or saline 1 h before the second episode of the forced swimming test (FST).
Tramadol or saline was intraperitoneally pretreated 30 min before the former administration of ketamine or saline.
The locomotor activity and the immobility time of FST were both measured.
After that, rats were sacrificed to determine the expression of mTOR in hippocampus and prefrontal cortex.
Tramadol at the dose of 5 mg/kg administrated alone did not elicit the antidepressant effects.
More importantly, pretreatment with tramadol enhanced the ketamine-induced antidepressant effects and upregulated the expression of mTOR in rat hippocampus and prefrontal cortex.
Pretreatment with tramadol enhances the ketamine-induced antidepressant effects, which is associated with the increased expression of mTOR in rat hippocampus and prefrontal cortex.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Chun& Li, Wen-Yuan& Yu, Hai-Yin& Gao, Zhi-Qin& Liu, Xiang-Liu& Zhou, Zhi-Qiang…[et al.]. 2012. Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. BioMed Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991484
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Chun…[et al.]. Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. BioMed Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991484
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Chun& Li, Wen-Yuan& Yu, Hai-Yin& Gao, Zhi-Qin& Liu, Xiang-Liu& Zhou, Zhi-Qiang…[et al.]. Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991484
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991484
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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