Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex
Joint Authors
Yang, Chun
Zhou, Zhi-Qiang
Gao, Zhi-Qin
Li, Wen-Yuan
Yu, Hai-Yin
Liu, Xiang-Liu
Yang, Jian-Jun
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Several lines of evidence have demonstrated that acute administration of ketamine elicits fast-acting antidepressant effects.
Moreover, tramadol also has potential antidepressant effects.
The aim of this study was to investigate the effects of pretreatment with tramadol on ketamine-induced antidepressant activity and was to determine the expression of mammalian target of rapamycin (mTOR) in rat hippocampus and prefrontal cortex.
Rats were intraperitoneally administrated with ketamine at the dose of 10 mg/kg or saline 1 h before the second episode of the forced swimming test (FST).
Tramadol or saline was intraperitoneally pretreated 30 min before the former administration of ketamine or saline.
The locomotor activity and the immobility time of FST were both measured.
After that, rats were sacrificed to determine the expression of mTOR in hippocampus and prefrontal cortex.
Tramadol at the dose of 5 mg/kg administrated alone did not elicit the antidepressant effects.
More importantly, pretreatment with tramadol enhanced the ketamine-induced antidepressant effects and upregulated the expression of mTOR in rat hippocampus and prefrontal cortex.
Pretreatment with tramadol enhances the ketamine-induced antidepressant effects, which is associated with the increased expression of mTOR in rat hippocampus and prefrontal cortex.
American Psychological Association (APA)
Yang, Chun& Li, Wen-Yuan& Yu, Hai-Yin& Gao, Zhi-Qin& Liu, Xiang-Liu& Zhou, Zhi-Qiang…[et al.]. 2012. Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. BioMed Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991484
Modern Language Association (MLA)
Yang, Chun…[et al.]. Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. BioMed Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-991484
American Medical Association (AMA)
Yang, Chun& Li, Wen-Yuan& Yu, Hai-Yin& Gao, Zhi-Qin& Liu, Xiang-Liu& Zhou, Zhi-Qiang…[et al.]. Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-991484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-991484