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Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
المؤلفون المشاركون
Yan, Zhimin
Hua, Hong
Xu, Yanying
Samaranayake, Lakshman P.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts.
The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays.
They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients.
It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients.
The MIC values ranged from 16 to 128 μg/mL.
More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed.
We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Zhimin& Hua, Hong& Xu, Yanying& Samaranayake, Lakshman P.. 2012. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992000
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Zhimin…[et al.]. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992000
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Zhimin& Hua, Hong& Xu, Yanying& Samaranayake, Lakshman P.. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992000
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992000
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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