Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
Joint Authors
Yan, Zhimin
Hua, Hong
Xu, Yanying
Samaranayake, Lakshman P.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts.
The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays.
They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients.
It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients.
The MIC values ranged from 16 to 128 μg/mL.
More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed.
We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
American Psychological Association (APA)
Yan, Zhimin& Hua, Hong& Xu, Yanying& Samaranayake, Lakshman P.. 2012. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992000
Modern Language Association (MLA)
Yan, Zhimin…[et al.]. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992000
American Medical Association (AMA)
Yan, Zhimin& Hua, Hong& Xu, Yanying& Samaranayake, Lakshman P.. Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-992000